Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease.
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
28 08 2019
28 08 2019
Historique:
received:
04
10
2018
revised:
24
12
2018
accepted:
27
04
2019
entrez:
30
8
2019
pubmed:
30
8
2019
medline:
28
7
2020
Statut:
ppublish
Résumé
Loss of function of TREM2, a key receptor selectively expressed by microglia in the brain, contributes to the development of Alzheimer's disease (AD). We therefore examined whether soluble TREM2 (sTREM2) concentrations in cerebrospinal fluid (CSF) were associated with reduced rates of cognitive decline and clinical progression in subjects with AD or mild cognitive impairment (MCI). We measured sTREM2 in CSF samples from 385 elderly subjects, including cognitively normal controls, individuals with MCI, and subjects with AD dementia (follow-up period: mean, 4 years; range 1.5 to 11.5 years). In subjects with AD defined by evidence of CSF Aβ
Identifiants
pubmed: 31462511
pii: 11/507/eaav6221
doi: 10.1126/scitranslmed.aav6221
pmc: PMC7050285
mid: NIHMS1562253
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Membrane Glycoproteins
0
Receptors, Immunologic
0
TREM2 protein, human
0
tau Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : P30 AG010124
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG053303
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG058501
Pays : United States
Organisme : CIHR
Pays : Canada
Organisme : NIA NIH HHS
ID : T32 AG000213
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG035083
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG058922
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG044546
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS085419
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG003991
Pays : United States
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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