The olfactory mucosa, first actor of olfactory detection, is sensitive to glucocorticoid hormone.
NR3C1
dexamethasone
epithelium
olfaction
stress
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
09
05
2019
revised:
16
08
2019
accepted:
22
08
2019
pubmed:
30
8
2019
medline:
22
6
2021
entrez:
30
8
2019
Statut:
ppublish
Résumé
The olfactory mucosa (OM) is the primary site of odorant detection, and its axonal projections relay information to brain structures for signal processing. We have previously observed that olfactory function can be affected during a prolonged stress challenge in Wistar rats. The stress response is a neuroendocrine retro-controlled loop allowing pleiotropic adaptive tissue alterations, which are partly mediated through the release of glucocorticoid hormones. We hypothesised that, as part of their wide-ranging pleiotropic effects, glucocorticoids might affect the first step of olfactory detection. To study this, we used a number of approaches ranging from the molecular detection and functional characterisation of glucocorticoid receptors (GRs) in OM cells, to the study of GR acute activation in vivo at the molecular, electrophysiological and behavioural levels. In contrast to previous reports, where GR was reported to be exclusive in olfactory sensory neurones, we located functional GR expression mostly in olfactory ensheathing cells. Dexamethasone (2 mg/kg) was injected intraperitoneally to activate GR in vivo, and this led to functional odorant electrophysiological response (electro-olfactogram) and OM gene expression changes. In a habituation/cross-habituation test of olfactory sensitivity, we observed that DEX-treated rats exhibited higher responsiveness to a complex odorant mixture. These findings support the idea that olfactory perception is altered in stressed animals, as glucocorticoids might enhance odour detection, starting at the first step of detection.
Substances chimiques
Glucocorticoids
0
Receptors, Glucocorticoid
0
Banques de données
GENBANK
['M14053.1', 'NM_031144.2', 'M55075.1', 'NM_013113.2', 'NM_139254.2', 'NM_031530.1', 'NM_012928.1', 'NM_001191836.2', 'L41045.1', 'NM_012616.1', 'NM_012576.2', 'NM_031710.1', 'NP_005618.2']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1403-1418Subventions
Organisme : Institut National de la Recherche Agronomique
Pays : International
Informations de copyright
© 2019 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
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