Viral priming of cell intrinsic innate antiviral signaling by the unfolded protein response.
Animals
Antiviral Agents
/ pharmacology
Chlorocebus aethiops
DEAD Box Protein 58
/ metabolism
Dengue
/ immunology
Dengue Virus
/ drug effects
Encephalitis Viruses, Tick-Borne
/ drug effects
Encephalitis, Tick-Borne
/ immunology
Endoribonucleases
/ metabolism
Female
Flavivirus Infections
/ immunology
Host-Pathogen Interactions
/ physiology
Humans
Immunity, Innate
/ drug effects
Interferon Regulatory Factor-3
/ metabolism
Mice
Protein Serine-Threonine Kinases
/ metabolism
Receptors, Immunologic
Signal Transduction
/ drug effects
Transcriptome
Unfolded Protein Response
/ drug effects
Vero Cells
Virus Replication
/ drug effects
West Nile Fever
/ immunology
West Nile virus
/ drug effects
Zika Virus
/ drug effects
Zika Virus Infection
/ immunology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
29 08 2019
29 08 2019
Historique:
received:
15
08
2018
accepted:
19
07
2019
entrez:
31
8
2019
pubmed:
31
8
2019
medline:
7
1
2020
Statut:
epublish
Résumé
The innate response to a pathogen is critical in determining the outcome of the infection. However, the interplay of different cellular responses that are activated following viral infection and their contribution to innate antiviral signalling has not been clearly established. This work shows that flaviviruses, including Dengue, Zika, West Nile and Tick-borne encephalitis viruses, activate the unfolded protein response before transcription of interferon regulatory factor 3 induced genes. Infection in conditions of unfolded protein response priming leads to early activation of innate antiviral responses and cell intrinsic inhibition of viral replication, which is interferon regulatory factor 3 dependent. These results demonstrate that the unfolded protein response is not only a physiological reaction of the cell to viral infection, but also synergizes with pattern recognition sensing to mount a potent antiviral response.
Identifiants
pubmed: 31467282
doi: 10.1038/s41467-019-11663-2
pii: 10.1038/s41467-019-11663-2
pmc: PMC6715738
doi:
Substances chimiques
Antiviral Agents
0
IRF3 protein, human
0
Interferon Regulatory Factor-3
0
Receptors, Immunologic
0
ERN1 protein, human
EC 2.7.11.1
Protein Serine-Threonine Kinases
EC 2.7.11.1
Endoribonucleases
EC 3.1.-
RIGI protein, human
EC 3.6.1.-
DEAD Box Protein 58
EC 3.6.4.13
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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