Progranulin deficiency confers resistance to autoimmune encephalomyelitis in mice.
Adolescent
Adult
Animals
Antigen-Presenting Cells
/ immunology
Antigens
/ metabolism
Bone Marrow
/ pathology
Bone Marrow Transplantation
Dendritic Cells
/ metabolism
Disease Resistance
Encephalomyelitis, Autoimmune, Experimental
/ blood
Female
Histocompatibility Antigens Class II
/ metabolism
Humans
Lymphocyte Count
Macrophages
/ metabolism
Male
Mice, Inbred C57BL
Middle Aged
Multiple Sclerosis
/ blood
Myeloid Cells
/ pathology
Ovalbumin
Phagocytes
/ metabolism
Phagocytosis
Progranulins
/ blood
Scavenger Receptors, Class B
/ metabolism
T-Lymphocytes
/ immunology
Young Adult
Antigen processing
Autoimmune encephalomyelitis
Autoimmunity
Phagocytosis
Progranulin
Journal
Cellular & molecular immunology
ISSN: 2042-0226
Titre abrégé: Cell Mol Immunol
Pays: China
ID NLM: 101242872
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
14
04
2019
accepted:
02
08
2019
pubmed:
31
8
2019
medline:
1
10
2021
entrez:
31
8
2019
Statut:
ppublish
Résumé
Progranulin is a secreted neurotrophin that assists in the autophagolysosomal pathways that contribute to MHC-mediated antigen processing, pathogen removal, and autoimmunity. We showed that patients with multiple sclerosis (MS) have high levels of circulating progranulin and that its depletion in a mouse model by a monoclonal antibody aggravates MS-like experimental autoimmune encephalomyelitis (EAE). However, unexpectedly, progranulin-deficient mice (Grn
Identifiants
pubmed: 31467413
doi: 10.1038/s41423-019-0274-5
pii: 10.1038/s41423-019-0274-5
pmc: PMC7609649
doi:
Substances chimiques
Antigens
0
Histocompatibility Antigens Class II
0
Progranulins
0
Scavenger Receptors, Class B
0
Ovalbumin
9006-59-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1077-1091Commentaires et corrections
Type : CommentIn
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