Adipocyte-specific gp130 signalling mediates exercise-induced weight reduction.
Adipocytes
/ metabolism
Animals
Body Weight
/ physiology
Cytokine Receptor gp130
/ metabolism
Diet, High-Fat
Eating
/ physiology
Energy Metabolism
/ physiology
Insulin
/ metabolism
Leptin
/ metabolism
Male
Mice
Mice, Knockout
Obesity
/ metabolism
Physical Conditioning, Animal
/ physiology
Signal Transduction
/ physiology
Weight Loss
/ physiology
Journal
International journal of obesity (2005)
ISSN: 1476-5497
Titre abrégé: Int J Obes (Lond)
Pays: England
ID NLM: 101256108
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
04
03
2019
accepted:
15
07
2019
revised:
02
07
2019
pubmed:
31
8
2019
medline:
11
5
2021
entrez:
31
8
2019
Statut:
ppublish
Résumé
Repetitive physical activity is a well-established intervention to reduce obesity and to prevent weight regain. Besides increased energy expenditure, reduced caloric intake may contribute to exercise-induced weight loss in obesity. Using adipocyte-specific glycoprotein 130 knockout (gp130 gp130 Repetitive physical activity reduced food intake and HFD-induced weight gain in gp130 Adipocyte-specific IL-6 signalling is involved in exercise-mediated regulation of food intake and weight reduction in HFD-fed mice.
Sections du résumé
BACKGROUND
Repetitive physical activity is a well-established intervention to reduce obesity and to prevent weight regain. Besides increased energy expenditure, reduced caloric intake may contribute to exercise-induced weight loss in obesity. Using adipocyte-specific glycoprotein 130 knockout (gp130
METHODS
gp130
RESULTS
Repetitive physical activity reduced food intake and HFD-induced weight gain in gp130
CONCLUSION
Adipocyte-specific IL-6 signalling is involved in exercise-mediated regulation of food intake and weight reduction in HFD-fed mice.
Identifiants
pubmed: 31467419
doi: 10.1038/s41366-019-0444-7
pii: 10.1038/s41366-019-0444-7
doi:
Substances chimiques
Insulin
0
Leptin
0
Cytokine Receptor gp130
133483-10-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
707-714Références
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