Identification of novel epithelial ovarian cancer loci in women of African ancestry.

Black or African American / genetics Aldo-Keto Reductase Family 1 Member C3 / genetics Antigens, Neoplasm / genetics Black People / genetics Breast Neoplasms / epidemiology Carcinoma, Ovarian Epithelial / epidemiology Female Follistatin / genetics Genetic Predisposition to Disease / genetics Genome-Wide Association Study Humans Neoplasm Proteins / genetics Polymorphism, Single Nucleotide / genetics United States / epidemiology White People / genetics
African ancestry eQTLs gene expression genome wide association study ovarian cancer

Journal

International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124

Informations de publication

Date de publication:
01 06 2020
Historique:
received: 11 06 2019
revised: 29 07 2019
accepted: 12 08 2019
pubmed: 31 8 2019
medline: 8 1 2021
entrez: 31 8 2019
Statut: ppublish

Résumé

Women of African ancestry have lower incidence of epithelial ovarian cancer (EOC) yet worse survival compared to women of European ancestry. We conducted a genome-wide association study in African ancestry women with 755 EOC cases, including 537 high-grade serous ovarian carcinomas (HGSOC) and 1,235 controls. We identified four novel loci with suggestive evidence of association with EOC (p < 1 × 10

Identifiants

DOI: 10.1002/ijc.32653 PMID: 31469419 PMC: PMC7523187
pubmed: 31469419
doi: 10.1002/ijc.32653
pmc: PMC7523187
mid: NIHMS1631338
doi:

Substances chimiques

Antigens, Neoplasm 0
FST protein, human 0
Follistatin 0
MAGEC1 protein, human 0
Neoplasm Proteins 0
AKR1C3 protein, human EC 1.1.1.357
Aldo-Keto Reductase Family 1 Member C3 EC 1.1.1.357

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2987-2998

Subventions

Organisme : NCI NIH HHS
ID : U01 CA069417
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA164973
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA087538
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA087969
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA176726
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA058860
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000124
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA105009
Pays : United States
Organisme : NCI NIH HHS
ID : K07 CA080668
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA076292
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014089
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA160669
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA049449
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA218681
Pays : United States
Organisme : NCI NIH HHS
ID : N01 PC067010
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA159981
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA067262
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA095023
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA113148
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA058598
Pays : United States
Organisme : NCI NIH HHS
ID : K99 CA218681
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR025141
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA063464
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA115195
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA186107
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA054419
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA122443
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA015083
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA200854
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA076016
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA054281
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA063464
Pays : United States
Organisme : CIHR
Pays : Canada
Organisme : NCI NIH HHS
ID : U19 CA148112
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA149429
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA017054
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CN025403
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 ES044005
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA142081
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 ES049033
Pays : United States
Organisme : NCI NIH HHS
ID : K00 CA212222
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA071789
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA112523
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA164973
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA054281
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA136393
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA126841
Pays : United States
Organisme : Cancer Research UK
ID : 10119
Pays : United Kingdom

Informations de copyright

© 2019 UICC.

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Auteurs

Ani Manichaikul (A)

Center for Public Health Genomics, University of Virginia, Charlottesville, VA.
Department of Public Health Sciences, University of Virginia, Charlottesville, VA.

Lauren C Peres (LC)

Department of Public Health Sciences, University of Virginia, Charlottesville, VA.
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
ORCID: 0000-0002-6620-8600

Xin-Qun Wang (XQ)

Department of Public Health Sciences, University of Virginia, Charlottesville, VA.

Mollie E Barnard (ME)

Huntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, UT.

Deanna Chyn (D)

Department of Public Health Sciences, University of Virginia, Charlottesville, VA.

Xin Sheng (X)

Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA.

Zhaohui Du (Z)

Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA.
ORCID: 0000-0002-7125-8928

Jonathan Tyrer (J)

Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom.

Joseph Dennis (J)

Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom.

Ann G Schwartz (AG)

Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI.

Michele L Cote (ML)

Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI.

Edward Peters (E)

Epidemiology Program, Louisiana State University Health Sciences Center School of Public Health, New Orleans, LA.

Patricia G Moorman (PG)

Department of Community and Family Medicine, Duke University Medical Center, Durham, NC.

Melissa Bondy (M)

Cancer Prevention and Population Sciences Program, Baylor College of Medicine, Houston, TX.

Jill S Barnholtz-Sloan (JS)

Department of Population and Quantitative Health Sciences and Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH.
ORCID: 0000-0001-6190-9304

Paul Terry (P)

Department of Medicine, University of Tennessee Medical Center - Knoxville, Knoxville, TN.

Anthony J Alberg (AJ)

Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC.

Elisa V Bandera (EV)

Department of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ.

Ellen Funkhouser (E)

Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL.

Anna H Wu (AH)

Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA.

Celeste Leigh Pearce (CL)

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI.
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA.
ORCID: 0000-0002-8023-7846

Malcom Pike (M)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA.
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
ORCID: 0000-0003-4891-1199

Veronica Wendy Setiawan (VW)

Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA.

Christopher A Haiman (CA)

Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA.

Julie R Palmer (JR)

Slone Epidemiology Center at Boston University, Boston, MA.

Loic LeMarchand (L)

University of Hawaii Cancer Center, Honolulu, HI.

Lynne R Wilkens (LR)

University of Hawaii Cancer Center, Honolulu, HI.

Andrew Berchuck (A)

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC.

Jennifer A Doherty (JA)

Huntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, UT.

Francesmary Modugno (F)

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA.
Ovarian Cancer Center of Excellence, Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA.
ORCID: 0000-0003-0637-1534

Roberta Ness (R)

The University of Texas School of Public Health, Houston, TX.

Kirsten Moysich (K)

Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY.

Beth Y Karlan (BY)

Department of Obstetrics and Gynecology, Ronald Regan UCLA Medical Center, Los Angeles, CA.

Alice S Whittemore (AS)

Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA.
Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA.

Valerie McGuire (V)

Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA.

Weiva Sieh (W)

Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, NY, New York.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, NY, New York.

Kate Lawrenson (K)

Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA.
ORCID: 0000-0002-6469-2515

Simon Gayther (S)

Center for Bioinformatics and Functional Genomics and the Cedars-Sinai Genomics Core, Cedars-Sinai Medical Center, Los Angeles, CA.

Thomas A Sellers (TA)

Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

Paul Pharoah (P)

Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom.

Joellen M Schildkraut (JM)

Department of Public Health Sciences, University of Virginia, Charlottesville, VA.
ORCID: 0000-0002-0990-9339

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Classifications MeSH

questionsmedicales.fr › Personnes › Nord-Américains › Groupes de population aux États-Unis › Populations d'origine continentale › Noir ou Africain Américain › Identification of novel epithelial ovarian...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › Hydroxyprostaglandine dehydrogenases › Aldo-keto reductase family 1 member C3 › Identification of novel epithelial ovarian...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes néoplasiques › Identification of novel epithelial ovarian...
questionsmedicales.fr › Personnes › Noirs › Identification of novel epithelial ovarian...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Identification of novel epithelial ovarian...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Tumeurs de l'ovaire › Carcinome épithélial de l'ovaire › Identification of novel epithelial ovarian...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Follistatine › Identification of novel epithelial ovarian...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Identification of novel epithelial ovarian...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Identification of novel epithelial ovarian...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identification of novel epithelial ovarian...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Identification of novel epithelial ovarian...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Identification of novel epithelial ovarian...
questionsmedicales.fr › Régions géographiques › Amériques › Amérique du Nord › États-Unis › Identification of novel epithelial ovarian...
questionsmedicales.fr › Personnes › Blancs › Identification of novel epithelial ovarian...