Thromboxane A

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / pharmacology Animals Cells, Cultured Chemical and Drug Induced Liver Injury / metabolism Endothelial Cells / metabolism Male Mice, Inbred C57BL Mice, Knockout Monocrotaline Receptors, Thromboxane / agonists Signal Transduction
Endothelial Cells Liver Injury Monocrotaline Platelets SOS Thromboxane

Journal

Toxicology and applied pharmacology
ISSN: 1096-0333
Titre abrégé: Toxicol Appl Pharmacol
Pays: United States
ID NLM: 0416575

Informations de publication

Date de publication:
15 10 2019
Historique:
received: 03 07 2019
revised: 23 08 2019
accepted: 23 08 2019
pubmed: 31 8 2019
medline: 19 5 2020
entrez: 31 8 2019
Statut: ppublish

Résumé

Sinusoidal obstruction syndrome (SOS) is a major complication of chemotherapy and hematopoietic stem cell transplantation. The early stage of SOS is characterized by liver sinusoidal endothelial cell (LSEC) injury accompanied by platelet aggregation. Thromboxane A

Identifiants

DOI: 10.1016/j.taap.2019.114733 PMID: 31470032
pubmed: 31470032
pii: S0041-008X(19)30341-2
doi: 10.1016/j.taap.2019.114733
pii:
doi:

Substances chimiques

Receptors, Thromboxane 0
Monocrotaline 73077K8HYV
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid 76898-47-0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

114733

Informations de copyright

Copyright © 2019. Published by Elsevier Inc.

Auteurs

Fumisato Otaka (F)

Department of Molecular Pharmacology, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa 252-0374, Japan; Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan; Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan.

Yoshiya Ito (Y)

Department of Molecular Pharmacology, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa 252-0374, Japan; Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan.

Tomoyoshi Inoue (T)

Department of Molecular Pharmacology, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa 252-0374, Japan; Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan; Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan.

Hirotoki Ohkubo (H)

Department of Cardiovascular Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan.

Nobuyuki Nishizawa (N)

Department of Molecular Pharmacology, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa 252-0374, Japan; Department of Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan.

Ken Kojo (K)

Department of Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan.

Tomohiro Betto (T)

Department of Molecular Pharmacology, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa 252-0374, Japan; Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan; Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan.

Sakiko Yamane (S)

Department of Molecular Pharmacology, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa 252-0374, Japan; Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan; Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan.

Shuh Narumiya (S)

Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.

Wasaburo Koizumi (W)

Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan.

Masataka Majima (M)

Department of Molecular Pharmacology, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa 252-0374, Japan; Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan. Electronic address: mmajima@med.kitasto-u.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Prostaglandines synthétiques › Prostaglandines endoperoxydes synthétiques › Acide 15-hydroxy-11alpha,9alpha-(époxyméthano)prosta-5,13-diénoïque › Thromboxane A
questionsmedicales.fr › Eucaryotes › Animaux › Thromboxane A
questionsmedicales.fr › Cellules › Cellules cultivées › Thromboxane A
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Lésions hépatiques dues aux substances › Thromboxane A
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Thromboxane A
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Thromboxane A
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Thromboxane A
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Alcaloïdes de type pyrrolizidine › Monocrotaline › Thromboxane A
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs aux éicosanoïdes › Récepteur thromboxane › Thromboxane A
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Thromboxane A