Nuclear hormone receptors in parasitic Platyhelminths.

Animals Clonorchis sinensis / metabolism Echinococcus multilocularis / metabolism Evolution, Molecular Helminth Proteins / genetics Phylogeny Platyhelminths / metabolism Receptors, Cytoplasmic and Nuclear / chemistry Schistosoma / metabolism Schistosoma mansoni / metabolism
Evolution Gene duplication Nuclear receptors Platyhelminths

Journal

Molecular and biochemical parasitology
ISSN: 1872-9428
Titre abrégé: Mol Biochem Parasitol
Pays: Netherlands
ID NLM: 8006324

Informations de publication

Date de publication:
10 2019
Historique:
received: 12 07 2019
revised: 21 08 2019
accepted: 24 08 2019
pubmed: 31 8 2019
medline: 23 6 2020
entrez: 31 8 2019
Statut: ppublish

Résumé

Nuclear receptors (NRs) belong to a large protein superfamily which includes intracellular receptors for secreted hydrophobic signal molecules, such as steroid hormones and thyroid hormones. They regulate development and reproduction in metazoans by binding to the promoter region of their target gene to activate or repress mRNA synthesis. Isolation and characterization of NRs in the parasitic trematode Schistosoma mansoni identified two homologues of mammalian thyroid receptor (TR). This was the first known protostome exhibiting TR homologues. Three novel NRs each possess a novel set of two DNA binding domains (DBD) in tandem with a ligand binding domain (LBD) (2DBD-NRs) isolated in Schistosoma mansoni revealed a novel NR modular structure: A/B-DBD-DBD-hinge-LBD. Full length cDNA of several NRs have been isolated and studied in the parasitic trematodes S. mansoni, S. japonicum and in the cestode Echinococcus multilocularis. The genome of the blood flukes S. mansoni, S. japonicum and S. haematobium, the liver fluke Clonorchis sinensis and the cestode Echinococcus multilocularis have been sequenced. Study of the NR complement in parasitic Platyhelminths will help us to understand the role of NRs in regulation of their development and understand the evolution of NR in animals.

Identifiants

DOI: 10.1016/j.molbiopara.2019.111218 PMID: 31470045 PMC: PMC6783382
pubmed: 31470045
pii: S0166-6851(19)30101-X
doi: 10.1016/j.molbiopara.2019.111218
pmc: PMC6783382
mid: NIHMS1539562
pii:
doi:

Substances chimiques

Helminth Proteins 0
Receptors, Cytoplasmic and Nuclear 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

111218

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI046762
Pays : United States

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

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Auteurs

Wenjie Wu (W)

Departments of Biochemistry and Structural Biology and Pathology and Laboratory Medicine, University of Texas Health Sciences Center, San Antonio, TX, 78229-3800, USA.

Philip T LoVerde (PT)

Departments of Biochemistry and Structural Biology and Pathology and Laboratory Medicine, University of Texas Health Sciences Center, San Antonio, TX, 78229-3800, USA. Electronic address: loverde@uthscsa.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Nuclear hormone receptors in parasitic Platyhelminths.
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Plathelminthes › Trematoda › Opisthorchidae › Clonorchis sinensis › Nuclear hormone receptors in parasitic Platyhelminths.
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Plathelminthes › Cestoda › Echinococcus › Echinococcus multilocularis › Nuclear hormone receptors in parasitic Platyhelminths.
questionsmedicales.fr › Phénomènes biologiques › Évolution biologique › Évolution moléculaire › Nuclear hormone receptors in parasitic Platyhelminths.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'helminthes › Nuclear hormone receptors in parasitic Platyhelminths.
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Nuclear hormone receptors in parasitic Platyhelminths.
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Plathelminthes › Nuclear hormone receptors in parasitic Platyhelminths.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Nuclear hormone receptors in parasitic Platyhelminths.
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Plathelminthes › Trematoda › Schistosomatidae › Schistosoma › Nuclear hormone receptors in parasitic Platyhelminths.
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Plathelminthes › Trematoda › Schistosomatidae › Schistosoma › Schistosoma mansoni › Nuclear hormone receptors in parasitic Platyhelminths.