Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons.

Animals Cell Line Epithelial Cells / immunology Humans Inflammation / immunology Interferon Regulatory Factor-1 / immunology Interferon Type I / immunology Interferons / immunology Male Mice Mice, Inbred C57BL STAT1 Transcription Factor / immunology Interferon Lambda
chemokines epithelial cells inflammation interferon lambda interferon regulatory factor 1 interferons

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
17 09 2019
Historique:
received: 29 05 2018
revised: 20 05 2019
accepted: 25 07 2019
pubmed: 1 9 2019
medline: 18 12 2019
entrez: 1 9 2019
Statut: ppublish

Résumé

Type I and III interferons (IFNs) activate similar downstream signaling cascades, but unlike type I IFNs, type III IFNs (IFNλ) do not elicit strong inflammatory responses in vivo. Here, we examined the molecular mechanisms underlying this disparity. Type I and III IFNs displayed kinetic differences in expression of IFN-stimulated genes and proinflammatory responses, with type I IFNs preferentially stimulating expression of the transcription factor IRF1. Type III IFNs failed to induce IRF1 expression because of low IFNλ receptor abundance and insufficient STAT1 activation on epithelial cells and thus did not activate the IRF1 proinflammatory gene program. Rather, IFNλ stimulation preferentially induced factors implicated in tissue repair. Our findings suggest that IFN receptor compartmentalization and abundance confer a spatiotemporal division of labor where type III IFNs control viral spread at the site of the infection while restricting tissue damage; the transient induction of inflammatory responses by type I IFNs recruits immune effectors to promote protective immunity.

Identifiants

DOI: 10.1016/j.immuni.2019.07.007 PMID: 31471108 PMC: PMC7447158
pubmed: 31471108
pii: S1074-7613(19)30323-1
doi: 10.1016/j.immuni.2019.07.007
pmc: PMC7447158
mid: NIHMS1536525
pii:
doi:

Substances chimiques

IRF1 protein, human 0
Interferon Regulatory Factor-1 0
Interferon Type I 0
STAT1 Transcription Factor 0
Interferons 9008-11-1
Interferon Lambda 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

451-464.e6

Subventions

Organisme : NIAID NIH HHS
ID : T32 AI007509
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118896
Pays : United States
Organisme : NIH HHS
ID : P51 OD010425
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007312
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118916
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA178766
Pays : United States
Organisme : CCR NIH HHS
ID : HHSN261200800001C
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI100625
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
Organisme : NIAID NIH HHS
ID : DP2 AI136596
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI108765
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI127463
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI104002
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

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Auteurs

Adriana Forero (A)

Department of Immunology, School of Medicine, University of Washington, Seattle, WA 98109, USA.

Snehal Ozarkar (S)

Department of Immunology, School of Medicine, University of Washington, Seattle, WA 98109, USA.

Hongchuan Li (H)

Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

Chia Heng Lee (CH)

Department of Immunology, School of Medicine, University of Washington, Seattle, WA 98109, USA.

Emily A Hemann (EA)

Department of Immunology, School of Medicine, University of Washington, Seattle, WA 98109, USA.

Marija S Nadjsombati (MS)

Department of Immunology, School of Medicine, University of Washington, Seattle, WA 98109, USA.

Matthew R Hendricks (MR)

Department of Immunology, School of Medicine, University of Washington, Seattle, WA 98109, USA.

Lomon So (L)

Department of Immunology, School of Medicine, University of Washington, Seattle, WA 98109, USA.

Richard Green (R)

Department of Immunology, School of Medicine, University of Washington, Seattle, WA 98109, USA; Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA.

Chandra N Roy (CN)

University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA.

Saumendra N Sarkar (SN)

University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA.

Jakob von Moltke (J)

Department of Immunology, School of Medicine, University of Washington, Seattle, WA 98109, USA.

Stephen K Anderson (SK)

Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.

Michael Gale (M)

Department of Immunology, School of Medicine, University of Washington, Seattle, WA 98109, USA; Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA.

Ram Savan (R)

Department of Immunology, School of Medicine, University of Washington, Seattle, WA 98109, USA; Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA. Electronic address: savanram@uw.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Differential Activation of the Transcription...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Differential Activation of the Transcription...
questionsmedicales.fr › Cellules › Cellules épithéliales › Differential Activation of the Transcription...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Differential Activation of the Transcription...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Differential Activation of the Transcription...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de régulation d'interféron › Facteur-1 de régulation d'interféron › Differential Activation of the Transcription...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Interféron de type I › Differential Activation of the Transcription...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Differential Activation of the Transcription...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Differential Activation of the Transcription...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Differential Activation of the Transcription...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription STAT › Facteur de transcription STAT-1 › Differential Activation of the Transcription...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Interféron lambda › Differential Activation of the Transcription...