Ram Savan

Affiliations

Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA.

Publications (23)

IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease.

Blood

Avec: Andrea S Henden , Motoko Koyama , Renee J Robb , Adriana Forero , Rachel D Kuns , Karshing Chang , Kathleen S Ensbey , Antiopi Varelias , Stephen H Kazakoff , Nicole Waddell , Andrew D Clouston , Rabina Giri , Jakob Begun , Bruce R Blazar , Mariapia A Degli-Esposti , Sergei V Kotenko , Steven W Lane , Kate L Bowerman , Ram Savan , Philip Hugenholtz , Kate H Gartlan , Geoffrey R Hill

CELLULAR RNA INTERACTS WITH MAVS TO PROMOTE ANTIVIRAL SIGNALING.

bioRxiv : the preprint server for biology

Avec: Nandan S Gokhale , Kim Somfleth , Matthew G Thompson , Russell K Sam , Daphnée M Marciniak , Lan H Chu , Moonhee Park , Steve Dvorkin , Andrew Oberst , Stacy M Horner , Shao-En Ong , Michael Gale , Ram Savan

A small sustained increase in NOD1 abundance promotes ligand-independent inflammatory and oncogene transcriptional responses.

Science signaling

Avec: Leah M Rommereim , Ajay Suresh Akhade , Bhaskar Dutta , Carolyn Hutcheon , Nicolas W Lounsbury , Clifford C Rostomily , Ram Savan , Iain D C Fraser , Ronald N Germain , Naeha Subramanian

Flavivirus Nonstructural Protein NS5 Dysregulates HSP90 to Broadly Inhibit JAK/STAT Signaling.

Cells

Avec: Justin A Roby , Katharina Esser-Nobis , Elyse C Dewey-Verstelle , Marian R Fairgrieve , Johannes Schwerk , Amy Y Lu , Frank W Soveg , Emily A Hemann , Lauren D Hatfield , Brian C Keller , Alexander Shapiro , Adriana Forero , Jennifer E Stencel-Baerenwald , Ram Savan , Michael Gale

The RNA binding protein Arid5a drives IL-17-dependent autoantibody-induced glomerulonephritis.

The Journal of experimental medicine

Avec: Yang Li , Shachi P Vyas , Isha Mehta , Nariaki Asada , Ipsita Dey , Tiffany C Taylor , Rami Bechara , Nilesh Amatya , Felix E Y Aggor , Bianca M Coleman , De-Dong Li , Kenta Yamamoto , Ogechukwu Ezenwa , Yeque Sun , Esta Sterneck , C Joel McManus , Ulf Panzer , Partha S Biswas , Ram Savan , Jishnu Das , Sarah L Gaffen

Innate Immunity in Hepatitis C Virus Infection.

Cold Spring Harbor perspectives in medicine

Avec: Johannes Schwerk , Amina Negash , Ram Savan , Michael Gale

RNA regulatory mechanisms that control antiviral innate immunity.

Immunological reviews

Avec: Nandan S Gokhale , Julian R Smith , Rachel D Van Gelder , Ram Savan

ADAR1 mutation causes ZBP1-dependent immunopathology.

Nature

Avec: Nicholas W Hubbard , Joshua M Ames , Megan Maurano , Lan H Chu , Kim Y Somfleth , Nandan S Gokhale , Margo Werner , Jessica M Snyder , Katrina Lichauco , Ram Savan , Daniel B Stetson , Andrew Oberst

Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome.

bioRxiv : the preprint server for biology

Avec: Brian V Tsu , Rimjhim Agarwal , Nandan S Gokhale , Jessie Kulsuptrakul , Andrew P Ryan , Lennice K Castro , Christopher M Beierschmitt , Elizabeth A Turcotte , Elizabeth J Fay , Russell E Vance , Jennifer L Hyde , Ram Savan , Patrick S Mitchell , Matthew D Daugherty

Host-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome.

PLoS biology

Avec: Brian V Tsu , Rimjhim Agarwal , Nandan S Gokhale , Jessie Kulsuptrakul , Andrew P Ryan , Elizabeth J Fay , Lennice K Castro , Christopher Beierschmitt , Christina Yap , Elizabeth A Turcotte , Sofia E Delgado-Rodriguez , Russell E Vance , Jennifer L Hyde , Ram Savan , Patrick S Mitchell , Matthew D Daugherty

Innate immunity and interferon in SARS-CoV-2 infection outcome.

Immunity

Avec: Ram Savan , Michael Gale

Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons.

Immunity

Avec: Adriana Forero , Snehal Ozarkar , Hongchuan Li , Chia Heng Lee , Emily A Hemann , Marija S Nadjsombati , Matthew R Hendricks , Lomon So , Richard Green , Chandra N Roy , Saumendra N Sarkar , Jakob von Moltke , Stephen K Anderson , Michael Gale , Ram Savan

RNA-binding protein isoforms ZAP-S and ZAP-L have distinct antiviral and immune resolution functions.

Nature immunology

Avec: Johannes Schwerk , Frank W Soveg , Andrew P Ryan , Kerri R Thomas , Lauren D Hatfield , Snehal Ozarkar , Adriana Forero , Alison M Kell , Justin A Roby , Lomon So , Jennifer L Hyde , Michael Gale , Matthew D Daugherty , Ram Savan

Shear stress associated with cardiopulmonary bypass induces expression of inflammatory cytokines and necroptosis in monocytes.

JCI insight

Avec: Lan N Tu , Lance Hsieh , Masaki Kajimoto , Kevin Charette , Nataliya Kibiryeva , Adriana Forero , Sarah Hampson , Jennifer A Marshall , James O'Brien , Marta Scatena , Michael A Portman , Ram Savan , Chris Benner , Alberto Aliseda , Muhammad Nuri , Douglas Bittel , Peter Pastuszko , Vishal Nigam

Germline SAMD9L truncation variants trigger global translational repression.

The Journal of experimental medicine

Avec: Eric J Allenspach , Frank Soveg , Laura S Finn , Lomon So , Jacquelyn A Gorman , Aaron B I Rosen , Suzanne Skoda-Smith , Marsha M Wheeler , Kaitlyn A Barrow , Lucille M Rich , Jason S Debley , Michael J Bamshad , Deborah A Nickerson , Ram Savan , Troy R Torgerson , David J Rawlings

IL-4, IL-13 and IFN-γ -induced genes in highly purified human neutrophils.

Cytokine

Avec: Laura Kummola , Tanja Salomaa , Zsuzsanna Ortutay , Ram Savan , Howard A Young , Ilkka S Junttila

The canonical antiviral protein oligoadenylate synthetase 1 elicits antibacterial functions by enhancing IRF1 translation.

Immunity

Avec: Munesh K Harioudh , Joseph Perez , Lomon So , Mayank Maheshwari , Thomas S Ebert , Veit Hornung , Ram Savan , A Rouf Banday , Michael S Diamond , Vijay A Rathinam , Saumendra N Sarkar

Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus.

Nature immunology

Avec: Emily A Hemann , Richard Green , J Bryan Turnbull , Ryan A Langlois , Ram Savan , Michael Gale

Interferon-λ at the Center of the Storm.

Immunity

Avec: Matthew R Hendricks , Ram Savan

Endomembrane targeting of human OAS1 p46 augments antiviral activity.

eLife

Avec: Frank W Soveg , Johannes Schwerk , Nandan S Gokhale , Karen Cerosaletti , Julian R Smith , Erola Pairo-Castineira , Alison M Kell , Adriana Forero , Shivam A Zaver , Katharina Esser-Nobis , Justin A Roby , Tien-Ying Hsiang , Snehal Ozarkar , Jonathan M Clingan , Eileen T McAnarney , Amy El Stone , Uma Malhotra , Cate Speake , Joseph Perez , Chiraag Balu , Eric J Allenspach , Jennifer L Hyde , Vineet D Menachery , Saumendra N Sarkar , Joshua J Woodward , Daniel B Stetson , John Kenneth Baillie , Jane H Buckner , Michael Gale , Ram Savan

Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production.

Immunity

Avec: Munesh K Harioudh , Joseph Perez , Zhenlu Chong , Sharmila Nair , Lomon So , Kevin D McCormick , Arundhati Ghosh , Lulu Shao , Rashmi Srivastava , Frank Soveg , Thomas S Ebert , Maninjay K Atianand , Veit Hornung , Ram Savan , Michael S Diamond , Saumendra N Sarkar

Regulatory T cells suppress CD4+ effector T cell activation by controlling protein synthesis.

The Journal of experimental medicine

Avec: Lomon So , Kazushige Obata-Ninomiya , Alex Hu , Virginia S Muir , Ayako Takamori , Jing Song , Jane H Buckner , Ram Savan , Steven F Ziegler

MEF2A suppresses stress responses that trigger DDX41-dependent IFN production.

Cell reports

Avec: Julian R Smith , Jack W Dowling , Matthew I McFadden , Andrew Karp , Johannes Schwerk , Joshua J Woodward , Ram Savan , Adriana Forero

Réseau de co-auteurs

Michael Gale 8 collaborations

Adriana Forero 7 collaborations

Nandan S Gokhale 6 collaborations

Lomon So 6 collaborations

Johannes Schwerk 5 collaborations

Jennifer L Hyde 4 collaborations

Saumendra N Sarkar 4 collaborations

Justin A Roby 3 collaborations

Frank W Soveg 3 collaborations

Emily A Hemann 3 collaborations

Julian R Smith 3 collaborations

Andrew P Ryan 3 collaborations

Matthew D Daugherty 3 collaborations

Snehal Ozarkar 3 collaborations

Joseph Perez 3 collaborations

Lan H Chu 2 collaborations

Andrew Oberst 2 collaborations

Katharina Esser-Nobis 2 collaborations

Lauren D Hatfield 2 collaborations

Daniel B Stetson 2 collaborations

Brian V Tsu 2 collaborations

Rimjhim Agarwal 2 collaborations

Jessie Kulsuptrakul 2 collaborations

Lennice K Castro 2 collaborations

Elizabeth A Turcotte 2 collaborations

Elizabeth J Fay 2 collaborations

Russell E Vance 2 collaborations

Patrick S Mitchell 2 collaborations

Matthew R Hendricks 2 collaborations

Richard Green 2 collaborations

Alison M Kell 2 collaborations

Eric J Allenspach 2 collaborations

Frank Soveg 2 collaborations

Munesh K Harioudh 2 collaborations

Thomas S Ebert 2 collaborations

Veit Hornung 2 collaborations

Michael S Diamond 2 collaborations

Joshua J Woodward 2 collaborations

Jane H Buckner 2 collaborations

Andrea S Henden 1 collaboration

Motoko Koyama 1 collaboration

Renee J Robb 1 collaboration

Rachel D Kuns 1 collaboration

Karshing Chang 1 collaboration

Kathleen S Ensbey 1 collaboration

Antiopi Varelias 1 collaboration

Stephen H Kazakoff 1 collaboration

Nicole Waddell 1 collaboration

Andrew D Clouston 1 collaboration

Rabina Giri 1 collaboration

Jakob Begun 1 collaboration

Bruce R Blazar 1 collaboration

Mariapia A Degli-Esposti 1 collaboration

Sergei V Kotenko 1 collaboration

Steven W Lane 1 collaboration

Kate L Bowerman 1 collaboration

Philip Hugenholtz 1 collaboration

Kate H Gartlan 1 collaboration

Geoffrey R Hill 1 collaboration

Kim Somfleth 1 collaboration

Matthew G Thompson 1 collaboration

Russell K Sam 1 collaboration

Daphnée M Marciniak 1 collaboration

Moonhee Park 1 collaboration

Steve Dvorkin 1 collaboration

Stacy M Horner 1 collaboration

Shao-En Ong 1 collaboration

Leah M Rommereim 1 collaboration

Ajay Suresh Akhade 1 collaboration

Bhaskar Dutta 1 collaboration

Carolyn Hutcheon 1 collaboration

Nicolas W Lounsbury 1 collaboration

Clifford C Rostomily 1 collaboration

Iain D C Fraser 1 collaboration

Ronald N Germain 1 collaboration

Naeha Subramanian 1 collaboration

Elyse C Dewey-Verstelle 1 collaboration

Marian R Fairgrieve 1 collaboration

Amy Y Lu 1 collaboration

Brian C Keller 1 collaboration

Alexander Shapiro 1 collaboration

Jennifer E Stencel-Baerenwald 1 collaboration

Yang Li 1 collaboration

Shachi P Vyas 1 collaboration

Isha Mehta 1 collaboration

Nariaki Asada 1 collaboration

Ipsita Dey 1 collaboration

Tiffany C Taylor 1 collaboration

Rami Bechara 1 collaboration

Nilesh Amatya 1 collaboration

Felix E Y Aggor 1 collaboration

Bianca M Coleman 1 collaboration

De-Dong Li 1 collaboration

Kenta Yamamoto 1 collaboration

Ogechukwu Ezenwa 1 collaboration

Yeque Sun 1 collaboration

Esta Sterneck 1 collaboration

C Joel McManus 1 collaboration

Ulf Panzer 1 collaboration

Partha S Biswas 1 collaboration

Jishnu Das 1 collaboration

Sarah L Gaffen 1 collaboration

Amina Negash 1 collaboration

Rachel D Van Gelder 1 collaboration

Nicholas W Hubbard 1 collaboration

Joshua M Ames 1 collaboration

Megan Maurano 1 collaboration

Kim Y Somfleth 1 collaboration

Margo Werner 1 collaboration

Jessica M Snyder 1 collaboration

Katrina Lichauco 1 collaboration

Christopher M Beierschmitt 1 collaboration

Christopher Beierschmitt 1 collaboration

Christina Yap 1 collaboration

Sofia E Delgado-Rodriguez 1 collaboration

Hongchuan Li 1 collaboration

Chia Heng Lee 1 collaboration

Marija S Nadjsombati 1 collaboration

Chandra N Roy 1 collaboration

Jakob von Moltke 1 collaboration

Stephen K Anderson 1 collaboration

Kerri R Thomas 1 collaboration

Lan N Tu 1 collaboration

Lance Hsieh 1 collaboration

Masaki Kajimoto 1 collaboration

Kevin Charette 1 collaboration

Nataliya Kibiryeva 1 collaboration

Sarah Hampson 1 collaboration

Jennifer A Marshall 1 collaboration

James O'Brien 1 collaboration

Marta Scatena 1 collaboration

Michael A Portman 1 collaboration

Chris Benner 1 collaboration

Alberto Aliseda 1 collaboration

Muhammad Nuri 1 collaboration

Douglas Bittel 1 collaboration

Peter Pastuszko 1 collaboration

Vishal Nigam 1 collaboration

Laura S Finn 1 collaboration

Jacquelyn A Gorman 1 collaboration

Aaron B I Rosen 1 collaboration

Suzanne Skoda-Smith 1 collaboration

Marsha M Wheeler 1 collaboration

Kaitlyn A Barrow 1 collaboration

Lucille M Rich 1 collaboration

Jason S Debley 1 collaboration

Michael J Bamshad 1 collaboration

Deborah A Nickerson 1 collaboration

Troy R Torgerson 1 collaboration

David J Rawlings 1 collaboration

Laura Kummola 1 collaboration

Tanja Salomaa 1 collaboration

Zsuzsanna Ortutay 1 collaboration

Howard A Young 1 collaboration

Ilkka S Junttila 1 collaboration

Mayank Maheshwari 1 collaboration

A Rouf Banday 1 collaboration

Vijay A Rathinam 1 collaboration

J Bryan Turnbull 1 collaboration

Ryan A Langlois 1 collaboration

Karen Cerosaletti 1 collaboration

Erola Pairo-Castineira 1 collaboration

Shivam A Zaver 1 collaboration

Tien-Ying Hsiang 1 collaboration

Jonathan M Clingan 1 collaboration

Eileen T McAnarney 1 collaboration

Amy El Stone 1 collaboration

Uma Malhotra 1 collaboration

Cate Speake 1 collaboration

Chiraag Balu 1 collaboration

Vineet D Menachery 1 collaboration

John Kenneth Baillie 1 collaboration

Zhenlu Chong 1 collaboration

Sharmila Nair 1 collaboration

Kevin D McCormick 1 collaboration

Arundhati Ghosh 1 collaboration

Lulu Shao 1 collaboration

Rashmi Srivastava 1 collaboration

Maninjay K Atianand 1 collaboration

Kazushige Obata-Ninomiya 1 collaboration

Alex Hu 1 collaboration

Virginia S Muir 1 collaboration

Ayako Takamori 1 collaboration

Jing Song 1 collaboration

Steven F Ziegler 1 collaboration

Jack W Dowling 1 collaboration

Matthew I McFadden 1 collaboration

Andrew Karp 1 collaboration