ADAR1 mutation causes ZBP1-dependent immunopathology.
Adenosine Deaminase
/ genetics
Animals
Caspase 8
/ genetics
Cell Death
Gene Deletion
Immune System Diseases
/ genetics
Inflammation
/ genetics
Mammals
/ genetics
Mutation
Protein Kinases
/ deficiency
RNA, Double-Stranded
/ metabolism
RNA-Binding Proteins
/ genetics
Receptor-Interacting Protein Serine-Threonine Kinases
/ deficiency
Signal Transduction
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
23
09
2021
accepted:
23
05
2022
pubmed:
22
7
2022
medline:
30
7
2022
entrez:
21
7
2022
Statut:
ppublish
Résumé
The RNA-editing enzyme ADAR1 is essential for the suppression of innate immune activation and pathology caused by aberrant recognition of self-RNA, a role it carries out by disrupting the duplex structure of endogenous double-stranded RNA species
Identifiants
pubmed: 35859177
doi: 10.1038/s41586-022-04896-7
pii: 10.1038/s41586-022-04896-7
pmc: PMC9339495
mid: NIHMS1817019
doi:
Substances chimiques
RNA, Double-Stranded
0
RNA-Binding Proteins
0
Protein Kinases
EC 2.7.-
Receptor-Interacting Protein Serine-Threonine Kinases
EC 2.7.11.1
Caspase 8
EC 3.4.22.-
Adenosine Deaminase
EC 3.5.4.4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
769-775Subventions
Organisme : NIAID NIH HHS
ID : R01 AI084914
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI153246
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI106677
Pays : United States
Organisme : NIH HHS
ID : R01 AI147177
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Limited.
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