Endomembrane targeting of human OAS1 p46 augments antiviral activity.
COVID-19
RNA virus
SARS-CoV-2
human
immunology
inflammation
innate immunity
interferon stimulated genes
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
03 08 2021
03 08 2021
Historique:
received:
08
06
2021
accepted:
11
06
2021
pubmed:
4
8
2021
medline:
18
8
2021
entrez:
3
8
2021
Statut:
epublish
Résumé
Many host RNA sensors are positioned in the cytosol to detect viral RNA during infection. However, most positive-strand RNA viruses replicate within a modified organelle co-opted from intracellular membranes of the endomembrane system, which shields viral products from cellular innate immune sensors. Targeting innate RNA sensors to the endomembrane system may enhance their ability to sense RNA generated by viruses that use these compartments for replication. Here, we reveal that an isoform of oligoadenylate synthetase 1, OAS1 p46, is prenylated and targeted to the endomembrane system. Membrane localization of OAS1 p46 confers enhanced access to viral replication sites and results in increased antiviral activity against a subset of RNA viruses including flaviviruses, picornaviruses, and SARS-CoV-2. Finally, our human genetic analysis shows that the
Identifiants
pubmed: 34342578
doi: 10.7554/eLife.71047
pii: 71047
pmc: PMC8357416
doi:
pii:
Substances chimiques
OAS1 protein, human
EC 2.7.7.-
2',5'-Oligoadenylate Synthetase
EC 2.7.7.84
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI108765
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI150214
Pays : United States
Organisme : NIH HHS
ID : AI127463
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI106677
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007312
Pays : United States
Organisme : NIH HHS
ID : AI145974
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI135437
Pays : United States
Organisme : NIH HHS
ID : AI104002
Pays : United States
Organisme : NIH HHS
ID : GM007270
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007270
Pays : United States
Organisme : NIH HHS
ID : AI118916
Pays : United States
Organisme : NIH HHS
ID : AI106677
Pays : United States
Organisme : NIAID NIH HHS
ID : F31 AI140530
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI145296
Pays : United States
Organisme : NIH HHS
ID : AI145974,AI108765,AI135437
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI084914
Pays : United States
Organisme : NIH HHS
ID : P51 OD010425
Pays : United States
Organisme : NIH HHS
ID : AI145296
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118916
Pays : United States
Organisme : NIH HHS
ID : AI108765
Pays : United States
Organisme : NIH HHS
ID : AI106677,GM007270,AI140530
Pays : United States
Organisme : NIH HHS
ID : T32 HL007312
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI145974
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_20004
Pays : United Kingdom
Organisme : NIH HHS
ID : AI135437
Pays : United States
Organisme : NIH HHS
ID : AI100625
Pays : United States
Organisme : NIH HHS
ID : S10 OD026741
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI104002
Pays : United States
Organisme : NIH HHS
ID : AI104002,AI118916,AI145296,AI127463,AI100625
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI127463
Pays : United States
Organisme : NIH HHS
ID : AI140530
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI100625
Pays : United States
Informations de copyright
© 2021, Soveg et al.
Déclaration de conflit d'intérêts
FS, JS, NG, KC, JS, EP, AK, AF, SZ, KE, JR, TH, SO, JC, EM, AS, UM, CS, JP, CB, EA, JH, VM, SS, JW, DS, JB, JB, MG, RS No competing interests declared
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