RNA regulatory mechanisms that control antiviral innate immunity.
RNA biology
RNA-binding proteins
antiviral immunity
interferon
non-coding RNAs
post-transcriptional regulation
Journal
Immunological reviews
ISSN: 1600-065X
Titre abrégé: Immunol Rev
Pays: England
ID NLM: 7702118
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
29
07
2021
received:
18
06
2021
accepted:
02
08
2021
pubmed:
19
8
2021
medline:
15
12
2021
entrez:
18
8
2021
Statut:
ppublish
Résumé
From the initial sensing of viral nucleotides by pattern recognition receptors, through the induction of type I and III interferons (IFN), upregulation of antiviral effector proteins, and resolution of the inflammatory response, each step of innate immune signaling is under tight control. Though innate immunity is often associated with broad regulation at the level of gene transcription, RNA-centric post-transcriptional processes have emerged as critical mechanisms for ensuring a proper antiviral response. Here, we explore the diverse RNA regulatory mechanisms that modulate the innate antiviral immune response, with a focus on RNA sensing by RIG-I-like receptors (RLR), interferon (IFN) and IFN signaling pathways, viral pathogenesis, and host genetic variation that contributes to these processes. We address the post-transcriptional interactions with RNA-binding proteins, non-coding RNAs, transcript elements, and modifications that control mRNA stability, as well as alternative splicing events that modulate the innate immune antiviral response.
Identifiants
pubmed: 34405416
doi: 10.1111/imr.13019
pmc: PMC8616819
mid: NIHMS1731461
doi:
Substances chimiques
Antiviral Restriction Factors
0
RNA, Viral
0
Receptors, Pattern Recognition
0
Interferons
9008-11-1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
77-96Subventions
Organisme : NIAID NIH HHS
ID : R21 AI147177
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI141823
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI145974
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR002318
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI106677
Pays : United States
Informations de copyright
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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