Position β57 of I-A

Alleles Animals CD4-Positive T-Lymphocytes / immunology Cell Line Diabetes Mellitus, Type 1 / genetics Female Insulin / immunology Major Histocompatibility Complex / genetics Mice Mice, Inbred NOD Peptides / immunology Receptors, Antigen, T-Cell / immunology

Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
30 08 2019
Historique:
received: 10 01 2019
accepted: 05 08 2019
entrez: 1 9 2019
pubmed: 1 9 2019
medline: 27 5 2020
Statut: ppublish

Résumé

The class II region of the major histocompatibility complex (MHC) locus is the main contributor to the genetic susceptibility to type 1 diabetes (T1D). The loss of an aspartic acid at position 57 of diabetogenic HLA-DQβ chains supports this association; this single amino acid change influences how TCRs recognize peptides in the context of HLA-DQ8 and I-A

Identifiants

DOI: 10.1126/sciimmunol.aaw6329 PMID: 31471352 PMC: PMC6816460
pubmed: 31471352
pii: 4/38/eaaw6329
doi: 10.1126/sciimmunol.aaw6329
pmc: PMC6816460
mid: NIHMS1055478
pii:
doi:

Substances chimiques

Insulin 0
Peptides 0
Receptors, Antigen, T-Cell 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : P01 AI042288
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK108868
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK058177
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK099317
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI114551
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK117138
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002550
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK120340
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK107541
Pays : United States
Organisme : NIDDK NIH HHS
ID : DP3 DK097605
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR001112
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR002551
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI125879
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI110963
Pays : United States

Informations de copyright

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Références

Diabetes. 2015 Jan;64(1):172-82
pubmed: 25157096
Nat Genet. 2015 Aug;47(8):898-905
pubmed: 26168013
Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10418-E10427
pubmed: 29133420
Diabetes. 2004 Dec;53(12):3115-9
pubmed: 15561941
J Immunol. 2002 Sep 1;169(5):2436-43
pubmed: 12193712
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13838-43
pubmed: 9391114
J Exp Med. 2017 Aug 7;214(8):2369-2385
pubmed: 28630088
Nucleic Acids Res. 2003 Jan 1;31(1):307-10
pubmed: 12520009
Nat Methods. 2006 Mar;3(3):191-7
pubmed: 16489336
J Immunol. 2009 Dec 15;183(12):7949-57
pubmed: 19923463
Nature. 1990 Jun 21;345(6277):722-4
pubmed: 2113614
Nature. 2018 Aug;560(7716):107-111
pubmed: 30022165
J Exp Med. 2013 Oct 21;210(11):2403-14
pubmed: 24127484
J Immunol. 2003 Jan 1;170(1):123-31
pubmed: 12496391
Diabetes. 1998 Oct;47(10):1570-7
pubmed: 9753294
Immunity. 2010 Apr 23;32(4):457-67
pubmed: 20412756
J Immunol. 2017 Mar 1;198(5):1910-1920
pubmed: 28115529
Science. 2000 Apr 21;288(5465):505-11
pubmed: 10775108
Nat Immunol. 2016 Mar;17(3):304-14
pubmed: 26829766
J Exp Med. 2015 Nov 16;212(12):2041-56
pubmed: 26503446
PLoS One. 2011 Mar 31;6(3):e18401
pubmed: 21483785
Lancet. 1974 Oct 12;2(7885):864-6
pubmed: 4137711
Proc Natl Acad Sci U S A. 1999 May 11;96(10):5634-9
pubmed: 10318936
Front Endocrinol (Lausanne). 2018 Feb 23;9:51
pubmed: 29527189
Nature. 1987 Oct 15-21;329(6140):599-604
pubmed: 3309680
Nature. 1990 Jun 21;345(6277):724-6
pubmed: 1972779
Immunity. 1998 Mar;8(3):319-29
pubmed: 9529149
J Exp Med. 2011 Nov 21;208(12):2375-83
pubmed: 22065673
Nature. 2005 May 12;435(7039):220-3
pubmed: 15889095
Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16729-34
pubmed: 21949373
J Immunol. 2007 May 15;178(10):6051-7
pubmed: 17475829
Diabetologia. 2010 Sep;53(9):1958-70
pubmed: 20490452
J Immunol. 2009 Jan 15;182(2):766-73
pubmed: 19124719
Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14103-14108
pubmed: 27872297
J Immunol. 2000 May 1;164(9):4706-12
pubmed: 10779776
J Clin Invest. 2003 Sep;112(6):902-14
pubmed: 12975475
J Exp Med. 1996 May 1;183(5):2087-95
pubmed: 8642319
J Biol Chem. 2012 Mar 16;287(12):9514-24
pubmed: 22184118
Methods Mol Biol. 2018;1712:217-238
pubmed: 29224077
J Leukoc Biol. 2002 Nov;72(5):921-31
pubmed: 12429713
Nat Rev Genet. 2011 Oct 18;12(11):781-92
pubmed: 22005987
Nat Protoc. 2009;4(11):1649-52
pubmed: 19876025
Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10732-10737
pubmed: 30275329
Nature. 1987 Mar 19-25;326(6110):304-6
pubmed: 3102976
Nature. 2008 Nov 27;456(7221):534-8
pubmed: 19037317
Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14074-9
pubmed: 16966600
J Clin Invest. 2010 May;120(5):1578-90
pubmed: 20407212
Diabetes. 2008 Jul;57(7):1852-60
pubmed: 18398138
JCI Insight. 2018 Jan 25;3(2):
pubmed: 29367462
Immunity. 2000 Jun;12(6):699-710
pubmed: 10894169
J Immunol. 2000 Sep 15;165(6):3214-25
pubmed: 10975837
J Exp Med. 2009 Dec 21;206(13):3015-29
pubmed: 20008522
Lancet. 1974 Jun 22;1(7869):1269-75
pubmed: 4134154
Nature. 1990 Jun 21;345(6277):727-9
pubmed: 2163026
J Clin Invest. 2005 Aug;115(8):2268-76
pubmed: 16075062
Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10978-83
pubmed: 20534455
Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9566-70
pubmed: 8415742
J Immunol. 1995 May 15;154(10):5567-75
pubmed: 7730655

Auteurs

Louis Gioia (L)

Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.
ORCID: 0000-0003-1302-2340

Marie Holt (M)

Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.

Anne Costanzo (A)

Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.
ORCID: 0000-0003-1934-5319

Siddhartha Sharma (S)

Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.
ORCID: 0000-0001-8597-7547

Brian Abe (B)

Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.
ORCID: 0000-0002-1262-5556

Lisa Kain (L)

Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.

Maki Nakayama (M)

Department of Pediatrics and Department of Immunology and Microbiology, Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Denver, CO 80045, USA.
ORCID: 0000-0002-0009-3687

Xiaoxiao Wan (X)

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Andrew Su (A)

Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.
ORCID: 0000-0002-9859-4104

Clayton Mathews (C)

Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
ORCID: 0000-0002-8817-6355

Yi-Guang Chen (YG)

University of Florida College of Medicine, Gainesville, FL 32611, USA.

Emil Unanue (E)

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Luc Teyton (L)

Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA. lteyton@scripps.edu.
ORCID: 0000-0002-4049-1583

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Allèles › Position β57 of I-A
questionsmedicales.fr › Eucaryotes › Animaux › Position β57 of I-A
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Position β57 of I-A
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Position β57 of I-A
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Diabète de type 1 › Position β57 of I-A
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Position β57 of I-A
questionsmedicales.fr › Phénomènes du système immunitaire › Phénomènes immunogénétiques › Complexe majeur d'histocompatibilité › Position β57 of I-A
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Position β57 of I-A
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée NOD › Position β57 of I-A
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Position β57 of I-A
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Position β57 of I-A