The NIH Toolbox for cognitive surveillance in Duchenne muscular dystrophy.
Journal
Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
05
06
2019
revised:
15
07
2019
accepted:
16
07
2019
pubmed:
1
9
2019
medline:
19
5
2020
entrez:
1
9
2019
Statut:
ppublish
Résumé
We performed a prospective, cross-sectional cognitive assessment in subjects with Duchenne Muscular Dystrophy (DMD) and their biological mothers. Thirty subjects with out-of-frame mutations in the dystrophin (DMD) gene, and 25 biological mothers were evaluated using the National Institutes of Health Toolbox Cognition Battery (NIHTB-CB). A parent completed the Behavior Rating Inventory of Executive Functioning (BRIEF), a standardized rating scale of executive functioning, for their child. Mothers completed self-reports of BRIEF and Neuro Quality-of-Life (NeuroQoL) Cognitive Function. Overall, the subjects with DMD scored approximately one standard deviation (SD) below age-corrected norms on the NIHTB-CB Total Cognition score. They scored 1.5 SD below age-corrected norms in Fluid Cognition, which evaluates the cognitive domains of executive function, working memory, episodic memory, attention, and processing speed. Their performance was consistent with age expectations (i.e., within 1 SD below age-corrected norms) in Crystalized Cognition, which evaluates vocabulary and reading. Subjects with DMD had higher T-scores in several domains of BRIEF, demonstrating greater difficulty in executive functioning. The biological mothers had overall average or above average T-scores on NIHTB-CB. Mothers who were carriers of DMD mutation performed lower overall compared to mothers who were not carriers of DMD mutation (Cohen's d = -1.1). Carrier mothers performed lower than average (1.5 SD) in Executive Function, measured by Flanker Inhibitory Control and Attention. Biological mothers scored within expected score ranges for adults in BRIEF and NeuroQoL. The NIHTB-CB, combined with standardized self-reported measures, can be a sensitive screening tool for cognitive surveillance in DMD.
Identifiants
pubmed: 31472009
doi: 10.1002/acn3.50867
pmc: PMC6764624
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1696-1706Subventions
Organisme : American Academy of Neuromuscular and Electrodiagnostic Medicine
ID : Award Number AWD00001989
Pays : International
Organisme : American Academy
ID : 2017
Pays : International
Organisme : American Academy
ID : 2019
Pays : International
Organisme : American Academy
ID : AWD00001989
Pays : International
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
Références
Dev Med Child Neurol. 2008 Aug;50(8):638-9
pubmed: 18754906
Monogr Soc Res Child Dev. 2013 Aug;78(4):1-15
pubmed: 23952199
Mol Genet Metab. 2014 Sep-Oct;113(1-2):136-41
pubmed: 24881970
Neurosci Biobehav Rev. 2013 Jun;37(5):743-52
pubmed: 23545331
Neuromuscul Disord. 2013 Jul;23(7):529-39
pubmed: 23726376
J Child Neurol. 2017 Jun;32(7):663-670
pubmed: 28393671
Child Neuropsychol. 2002 Dec;8(4):249-57
pubmed: 12759822
Neurology. 2000 Jun 13;54(11):2127-32
pubmed: 10851376
J Pediatr Psychol. 2017 Sep 1;42(8):815-822
pubmed: 28369473
Percept Mot Skills. 2007 Apr;104(2):663-76
pubmed: 17566456
Neurology. 2015 May 26;84(21):2146-52
pubmed: 25925982
J Child Neurol. 2005 Oct;20(10):790-5
pubmed: 16417872
J Int Neuropsychol Soc. 2014 Jul;20(6):567-78
pubmed: 24959840
SAGE Open Med. 2019 Mar 02;7:2050312119834470
pubmed: 30854202
J Int Neuropsychol Soc. 2001 Jan;7(1):45-54
pubmed: 11253841
Neuromuscul Disord. 2007 Dec;17(11-12):986-94
pubmed: 17720499
Neurology. 2013 Mar 12;80(11 Suppl 3):S1
pubmed: 23479536
PLoS Curr. 2018 May 11;10:
pubmed: 30254788
Lancet Neurol. 2018 May;17(5):445-455
pubmed: 29398641
Child Neuropsychol. 2015;21(2):225-33
pubmed: 24650292
J Neurodev Disord. 2016 Sep 06;8(1):35
pubmed: 27602170
Neurology. 2013 Mar 12;80(11 Suppl 3):S2-6
pubmed: 23479538
Neurology. 2013 Mar 12;80(11 Suppl 3):S54-64
pubmed: 23479546
J Int Neuropsychol Soc. 2015 May;21(5):378-91
pubmed: 26030001
J Dev Behav Pediatr. 2015 Jul-Aug;36(6):455-63
pubmed: 26020585
PLoS One. 2015 Aug 14;10(8):e0133214
pubmed: 26275215
J Child Neurol. 2008 May;23(5):477-81
pubmed: 18354150
Arch Dis Child. 2007 Jul;92(7):647-9
pubmed: 17588982
Brain. 2003 Nov;126(Pt 11):2431-46
pubmed: 12958079
Dev Med Child Neurol. 2005 Apr;47(4):257-65
pubmed: 15832549
Cell. 1987 Dec 24;51(6):919-28
pubmed: 3319190
Dev Med Child Neurol. 2016 Jan;58(1):77-84
pubmed: 26365034
J Psychopharmacol. 2004 Mar;18(1):21-31
pubmed: 15107181
Neurology. 2012 Jun 5;78(23):1860-7
pubmed: 22573626
Neurology. 2018 Sep 25;91(13):e1215-e1219
pubmed: 30135256
Prog Neuropsychopharmacol Biol Psychiatry. 2001 Nov;25(8):1497-511
pubmed: 11642650
Lancet Neurol. 2003 Dec;2(12):731-40
pubmed: 14636778