Characterization of serotonin following exposure to antibiotics in white-tailed deer.
5-Hydroxytryptamine (5-HT)
Antibiotics
Gut microbiota
Neurotransmitters
Serotonin
White-tailed deer
Journal
General and comparative endocrinology
ISSN: 1095-6840
Titre abrégé: Gen Comp Endocrinol
Pays: United States
ID NLM: 0370735
Informations de publication
Date de publication:
01 01 2020
01 01 2020
Historique:
received:
28
06
2019
revised:
27
08
2019
accepted:
28
08
2019
pubmed:
2
9
2019
medline:
11
3
2020
entrez:
2
9
2019
Statut:
ppublish
Résumé
Developing baseline concentrations of serotonin in healthy white-tailed deer will allow for the development of a biomarker using non-invasive sample tissues in sick animals, for example, non-clinical cases of chronic wasting disease. It will also allow some further insight into whether the use of antibiotics as growth promoters (AGP), such as chlortetracycline, is affecting serotonin concentrations in white-tailed deer. Florfenicol and tulathromycin impacts on serotonin concentration changes were also investigated. An analytical method for the detection and confirmation of serotonin, 5-hydroxytryptamine (5-HT), in white-tailed deer tissues was developed and validated. Serum and urine samples were extracted with acetonitrile. Liquid chromatography separation was attained on a Phenomenex C
Identifiants
pubmed: 31473183
pii: S0016-6480(19)30330-2
doi: 10.1016/j.ygcen.2019.113265
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Disaccharides
0
Heterocyclic Compounds
0
Serotonin
333DO1RDJY
florfenicol
9J97307Y1H
Thiamphenicol
FLQ7571NPM
tulathromycin
Q839I13422
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
113265Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.