Stressors affect urocortin 1 and urocortin 2 gene expression in rat spleen: The role of glucocorticoids.
Glucocorticoids
Lipopolysaccharide
Spleen
Stress
Urocortin 1
Urocortin 2
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 11 2019
15 11 2019
Historique:
received:
03
06
2019
revised:
15
08
2019
accepted:
22
08
2019
pubmed:
2
9
2019
medline:
18
6
2020
entrez:
2
9
2019
Statut:
ppublish
Résumé
The mechanisms underlying stress-related modulation of immune function via urocortin 1 and urocortin 2 have been only vaguely described. Therefore, we investigated the effect of LPS injection or immobilization stress on gene expression of urocortin 1 and urocortin 2 in the rat spleen, along with the potential involvement of glucocorticoids. Our data showed: a) different regulation of urocortin 1 and urocortin 2 gene expression in the rat spleen under different stressful conditions (LPS vs. immobilization stress) and b) diverse effects of stress-induced adrenal glucocorticoids on this process. Our findings indicate a specific, rather than general regulation of splenic immune function by urocortins during stressful conditions.
Identifiants
pubmed: 31473519
pii: S0165-5728(19)30273-5
doi: 10.1016/j.jneuroim.2019.577030
pii:
doi:
Substances chimiques
Glucocorticoids
0
Ucn protein, rat
0
Urocortins
0
urocortin 3, rat
0
Corticotropin-Releasing Hormone
9015-71-8
Corticosterone
W980KJ009P
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
577030Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.