Lung cancer and end-of-life care: a systematic review and thematic synthesis of aggressive inpatient care.
aggressive care
end-of-life care
healthcare costs
lung cancer
Journal
BMJ supportive & palliative care
ISSN: 2045-4368
Titre abrégé: BMJ Support Palliat Care
Pays: England
ID NLM: 101565123
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
19
01
2019
revised:
30
07
2019
accepted:
14
08
2019
pubmed:
2
9
2019
medline:
26
2
2020
entrez:
2
9
2019
Statut:
ppublish
Résumé
Despite recent advances in thoracic oncology, most patients with metastatic lung cancer die within months of diagnosis. Aggressiveness of their end-of-life (EOL) care has been the subject of numerous studies. This study was undertaken to evaluate the literature on aggressive inpatient EOL care for lung cancer and analyse the evolution of its aggressiveness over time. A systematic international literature search restricted to English-language publications used terms associated with aggressiveness of care, EOL and their synonyms. Two independent researchers screened for eligibility and extracted all data and another a random 10% sample of the abstracts. Electronic Medline and Embase databases were searched (2000-20 September 2018). EOL-care aggressiveness was defined as follows: 1) chemotherapy administered during the last 14 days of life (DOL) or new chemotherapy regimen during the last 30 DOL; 2) >2 emergency department visits; 3) >1 hospitalisation during the last 30 DOL; 4) ICU admission during the last 30 DOL and 5) palliative care started <3 days before death. Among the 150 articles identified, 42 were retained for review: 1 clinical trial, 3 observational cohorts, 21 retrospective analyses and 17 administrative data-based studies. The percentage of patients subjected to aggressive therapy seems to have increased over time. Early management by palliative care teams seems to limit aggressive care. Our analysis indicated very frequent aggressive EOL care for patients with lung cancer, regardless of the definition used. The extent of that aggressiveness and its impact on healthcare costs warrant further studies.
Identifiants
pubmed: 31473652
pii: bmjspcare-2019-001770
doi: 10.1136/bmjspcare-2019-001770
pmc: PMC6923940
doi:
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
413-424Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
JAMA Oncol. 2016 Jul 1;2(7):957-8
pubmed: 27123556
Ann Intern Med. 2003 Apr 15;138(8):639-43
pubmed: 12693886
Am J Hosp Palliat Care. 2017 Aug;34(7):685-691
pubmed: 27207719
J Palliat Med. 2011 Aug;14(8):929-39
pubmed: 21767153
J Clin Oncol. 2008 Aug 10;26(23):3860-6
pubmed: 18688053
J Clin Oncol. 2009 Sep 20;27(27):4613-8
pubmed: 19704067
N Engl J Med. 2011 Aug 4;365(5):395-409
pubmed: 21714641
CA Cancer J Clin. 2013 Sep;63(5):349-63
pubmed: 23856954
Ann Oncol. 2012 Oct;23 Suppl 7:vii56-64
pubmed: 22997455
Support Care Cancer. 2006 Oct;14(10):1038-45
pubmed: 16572312
Ann Oncol. 2010 May;21 Suppl 5:v116-9
pubmed: 20555059
Cancer Res Treat. 2015 Oct;47(4):555-63
pubmed: 25687851
J Oncol Pract. 2018 Sep 28;:JOP1800515
pubmed: 30265173
Chest. 2014 Oct;146(4):916-923
pubmed: 25117058
BMC Palliat Care. 2015 Mar 13;14:4
pubmed: 25792971
J Palliat Med. 2016 Jan;19(1):42-50
pubmed: 26600474
Am Soc Clin Oncol Educ Book. 2012;:e70-6
pubmed: 24451835
Oncologist. 2006 Nov-Dec;11(10):1095-9
pubmed: 17110629
BMJ. 2014 Mar 04;348:g1219
pubmed: 24594868
Arch Intern Med. 2012 Aug 13;172(15):1133-42
pubmed: 22777380
BMJ. 1998 Sep 19;317(7161):771-5
pubmed: 9740561
J Palliat Med. 2009 Oct;12(10):867-8
pubmed: 19807230
Acta Oncol. 2017 Oct;56(10):1272-1276
pubmed: 28562152
J Clin Oncol. 2012 May 10;30(14):1715-24
pubmed: 22493340
J Natl Cancer Inst. 2017 Sep 1;109(9):
pubmed: 28954284
BMC Palliat Care. 2014 May 22;13:26
pubmed: 24917696
Oncologist. 2009 Jul;14(7):752-9
pubmed: 19596665
Ann Oncol. 2016 Sep;27(suppl 5):v1-v27
pubmed: 27664245
J Clin Oncol. 2011 Apr 20;29(12):1587-91
pubmed: 21402603
J Clin Oncol. 2017 Mar 10;35(8):834-841
pubmed: 28029308
J Clin Oncol. 2012 Feb 1;30(4):394-400
pubmed: 22203758
Int J Qual Health Care. 2005 Dec;17(6):505-9
pubmed: 15985505
Ann Intern Med. 2015 Jun 2;162(11):777-84
pubmed: 26030634
BMJ. 2003 Jul 26;327(7408):195-8
pubmed: 12881260
Support Care Cancer. 2015 Nov;23(11):3277-80
pubmed: 25900109
Clin Oncol (R Coll Radiol). 2001;13(3):204-8
pubmed: 11527297
Rev Mal Respir. 2015 Mar;32(3):256-61
pubmed: 25847203
Chest. 2010 Nov;138(5):1071-7
pubmed: 20363837
Ann Oncol. 2009 Sep;20(9):1555-9
pubmed: 19468033
N Engl J Med. 2010 Aug 19;363(8):733-42
pubmed: 20818875
Psychooncology. 2015 Dec;24(12):1731-7
pubmed: 25959002
JAMA. 2016 Jan 19;315(3):284-92
pubmed: 26784776
J Clin Oncol. 2006 Jul 20;24(21):3490-6
pubmed: 16849766
J Palliat Med. 2012 May;15(5):516-20
pubmed: 22577784
J Clin Oncol. 2004 Jan 15;22(2):315-21
pubmed: 14722041
J Clin Oncol. 2012 Dec 10;30(35):4387-95
pubmed: 23150700
BMJ Open. 2015 Dec 23;5(12):e009419
pubmed: 26700282
CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300
pubmed: 20610543
J Emerg Med. 2012 Nov;43(5):803-10
pubmed: 21269792
J Natl Cancer Inst. 2011 Jun 8;103(11):853-62
pubmed: 21593012
Cancer. 2008 Aug 15;113(4):826-33
pubmed: 18618579
J Palliat Med. 2011 Nov;14(11):1231-5
pubmed: 21877925
JAMA. 2009 Feb 11;301(6):651-9
pubmed: 19211472
J Palliat Med. 2015 Mar;18(3):270-3
pubmed: 25210851
Oncology. 2007;72(3-4):164-71
pubmed: 18097167
Cancer. 2017 Aug 15;123(16):3186-3194
pubmed: 28419414
J Clin Oncol. 2013 Apr 10;31(11):1471-7
pubmed: 23478057
J Oncol Pract. 2017 Sep;13(9):e760-e769
pubmed: 28829693
Cancer. 2015 Sep 15;121(18):3307-15
pubmed: 26031241
J Pain Symptom Manage. 2008 Mar;35(3):267-74
pubmed: 18248949
Oncologist. 2016 Jun;21(6):771-7
pubmed: 27091417
JAMA. 2016 Jan 19;315(3):272-83
pubmed: 26784775
J Palliat Med. 2010 Aug;13(8):945-8
pubmed: 20712464
Ann Oncol. 2009 Feb;20(2):343-8
pubmed: 18765460
J Natl Compr Canc Netw. 2017 Apr;15(4):504-535
pubmed: 28404761
Lancet. 2015 Feb 26;385 Suppl 1:S41
pubmed: 26312863
Br J Cancer. 1988 Sep;58(3):355-8
pubmed: 2460120
Tumori. 2011 Jan-Feb;97(1):30-4
pubmed: 21528660
J Clin Oncol. 2008 Aug 10;26(23):3832-7
pubmed: 18688049
J Clin Oncol. 2006 Sep 20;24(27):4479-84
pubmed: 16983117
J Clin Oncol. 2015 Feb 1;33(4):370-6
pubmed: 25534384
Cancer. 2010 Aug 1;116(15):3732-9
pubmed: 20564065
J Palliat Med. 2007 Aug;10(4):882-93
pubmed: 17803409
Support Care Cancer. 2016 Mar;24(3):1079-89
pubmed: 26253587
J Pain Symptom Manage. 2012 Jan;43(1):1-9
pubmed: 21802899
JAMA. 2008 Oct 8;300(14):1665-73
pubmed: 18840840
Ann Oncol. 2011 Nov;22(11):2375-80
pubmed: 21402621
J Palliat Med. 2012 May;15(5):510-5
pubmed: 22401312