Mechanistic insights into the aetiology of post-prandial decline in testosterone in reproductive-aged men.
Adolescent
Adult
Cross-Over Studies
Dietary Fats
/ adverse effects
Emulsions
/ administration & dosage
Fast Foods
/ adverse effects
Humans
Hypogonadism
/ blood
Infusions, Intravenous
Leydig Cells
/ metabolism
Male
Middle Aged
Obesity
/ complications
Phospholipids
/ administration & dosage
Postprandial Period
/ physiology
Reproduction
/ physiology
Soybean Oil
/ administration & dosage
Testosterone
/ blood
Young Adult
fat
food
inflammation
post-prandial
testosterone
Journal
Andrologia
ISSN: 1439-0272
Titre abrégé: Andrologia
Pays: Germany
ID NLM: 0423506
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
12
06
2019
revised:
04
08
2019
accepted:
08
08
2019
pubmed:
3
9
2019
medline:
3
4
2020
entrez:
3
9
2019
Statut:
ppublish
Résumé
Obesity is known to be associated with impaired testicular function potentially resulting in androgen deficiency and subfertility. While the underlying cause of obesity-related male hypogonadism is multi-factorial, here, we investigated the impact of dietary fat on testicular endocrine function. Ingestion of a high-fat "fast food" mixed meal, a common practice for obese men, produced a 25% fall in serum testosterone within an hour of eating, with levels remaining suppressed below fasting baseline for up to 4 hr. These changes in serum testosterone were not associated with any significant changes in serum gonadotrophins. The nadir in serum testosterone preceded the post-prandial increase in serum IL-6/IL-17 by several hours, suggesting that inflammation was unlikely the cause. Furthermore, intravenous administration of fat (Intralipid) had no impact on testosterone levels, while an identical oral dose of fat did suppress testosterone. These results suggest that fat does not directly impair Leydig cell function, but rather the passage of fat through the intestinal tract elicits a response that indirectly elicits a post-prandial fall in testosterone.
Substances chimiques
Dietary Fats
0
Emulsions
0
Phospholipids
0
soybean oil, phospholipid emulsion
0
Testosterone
3XMK78S47O
Soybean Oil
8001-22-7
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13418Informations de copyright
© 2019 Blackwell Verlag GmbH.
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