Bronchodilation induced by PGE
Adult
Aged
Aged, 80 and over
Antihypertensive Agents
/ metabolism
Bronchi
/ drug effects
Bronchodilator Agents
/ metabolism
Dinoprostone
/ metabolism
Dose-Response Relationship, Drug
Epoprostenol
/ analogs & derivatives
Female
Humans
Hypertension, Pulmonary
/ drug therapy
Iloprost
/ metabolism
Male
Middle Aged
Organ Culture Techniques
Pyrrolidinones
/ metabolism
Receptors, Prostaglandin E, EP4 Subtype
/ agonists
Tetrazoles
/ metabolism
Vasodilator Agents
/ metabolism
Young Adult
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
16
05
2019
revised:
20
08
2019
accepted:
22
08
2019
pubmed:
3
9
2019
medline:
10
4
2021
entrez:
3
9
2019
Statut:
ppublish
Résumé
In patients with pulmonary hypertension (PH) associated with lung disease and/or hypoxia (Group III), decreased pulmonary vascular tone and tissue hypoxia is therapeutically beneficial. PGE Relaxation of bronchial muscle was assessed in samples isolated from control and PH Group III patients. Expression of prostanoid receptors was analysed by western blot and real-time PCR, and endogenous PGE Maximal relaxations induced by different EP The PGI
Sections du résumé
BACKGROUND AND PURPOSE
In patients with pulmonary hypertension (PH) associated with lung disease and/or hypoxia (Group III), decreased pulmonary vascular tone and tissue hypoxia is therapeutically beneficial. PGE
EXPERIMENTAL APPROACH
Relaxation of bronchial muscle was assessed in samples isolated from control and PH Group III patients. Expression of prostanoid receptors was analysed by western blot and real-time PCR, and endogenous PGE
KEY RESULTS
Maximal relaxations induced by different EP
CONCLUSION AND IMPLICATIONS
The PGI
Identifiants
pubmed: 31476020
doi: 10.1111/bph.14854
pmc: PMC6976782
doi:
Substances chimiques
Antihypertensive Agents
0
Bronchodilator Agents
0
Pyrrolidinones
0
Receptors, Prostaglandin E, EP4 Subtype
0
Tetrazoles
0
Vasodilator Agents
0
L-902688
D17QSK5F4B
Epoprostenol
DCR9Z582X0
Iloprost
JED5K35YGL
Dinoprostone
K7Q1JQR04M
treprostinil
RUM6K67ESG
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
161-174Subventions
Organisme : United Therapeutics Corporation
Pays : International
Informations de copyright
© 2019 The British Pharmacological Society.
Références
Eur Heart J. 2016 Jan 1;37(1):67-119
pubmed: 26320113
J Heart Lung Transplant. 2010 Feb;29(2):137-49
pubmed: 20022264
Prostaglandins Other Lipid Mediat. 2013 Dec;107:48-55
pubmed: 23850788
Am J Respir Crit Care Med. 1994 May;149(5):1138-41
pubmed: 8173753
Pulm Circ. 2017 Feb 1;7(1):82-88
pubmed: 28680567
Cardiovasc Ther. 2013 Feb;31(1):38-44
pubmed: 22970909
Lancet Respir Med. 2016 Apr;4(4):323-36
pubmed: 26975811
Br J Pharmacol. 2020 Jan;177(1):161-174
pubmed: 31476020
Eur J Clin Pharmacol. 1973 Aug;6(2):127-32
pubmed: 4588852
Thorax. 2002 Jun;57(6):473-6
pubmed: 12037220
Biochem Pharmacol. 2012 Jul 1;84(1):68-75
pubmed: 22480736
Int J Clin Pharm. 2013 Jun;35(3):313-5
pubmed: 23549775
Prostaglandins. 1987 Jun;33(6):845-54
pubmed: 2445003
Am J Physiol Lung Cell Mol Physiol. 2015 Feb 1;308(3):L229-52
pubmed: 25416383
Respir Med. 2007 Feb;101(2):217-22
pubmed: 16831539
Thorax. 1982 Jun;37(6):430-7
pubmed: 7135277
Int J Mol Sci. 2018 Aug 12;19(8):
pubmed: 30103548
Am J Respir Crit Care Med. 2008 Jul 15;178(2):188-96
pubmed: 18467507
Am Rev Respir Dis. 1993 Jul;148(1):87-90
pubmed: 8317820
Eur Respir J. 2019 Jan 24;53(1):
pubmed: 30545968
Am J Respir Crit Care Med. 2010 Nov 1;182(9):1161-70
pubmed: 20622039
J Am Coll Cardiol. 2006 Oct 17;48(8):1672-81
pubmed: 17045906
Br J Pharmacol. 2018 Apr;175(7):987-993
pubmed: 29520785
Nucleic Acids Res. 2018 Jan 4;46(D1):D1091-D1106
pubmed: 29149325
Ann Am Thorac Soc. 2015 Feb;12(2):269-73
pubmed: 25590376
Am J Respir Cell Mol Biol. 2006 Feb;34(2):242-6
pubmed: 16239641
Eur Respir J. 2009 Jul;34(1):132-7
pubmed: 19251782
J Pharmacol Exp Ther. 2009 Oct;331(1):297-307
pubmed: 19584306
Am J Respir Crit Care Med. 1995 Oct;152(4 Pt 1):1347-52
pubmed: 7551393
Am J Respir Cell Mol Biol. 2013 Mar;48(3):322-9
pubmed: 23221043
J Allergy Clin Immunol. 2015 Nov;136(5):1232-9.e1
pubmed: 25962903
Thorax. 2015 Aug;70(8):740-7
pubmed: 25939749
Chest. 1983 May;83(5):732-8
pubmed: 6839814
J Biol Chem. 2005 Jun 24;280(25):23451-63
pubmed: 15833737
Br J Clin Pharmacol. 1981 Nov;12(5):731-5
pubmed: 7332739
Thorax. 2011 Dec;66(12):1029-35
pubmed: 21606476
J Cell Physiol. 2012 Dec;227(12):3756-67
pubmed: 22378492
Intern Med. 2011;50(20):2341-6
pubmed: 22001462
Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93
pubmed: 10634944
Am J Respir Crit Care Med. 1999 Aug;160(2):600-7
pubmed: 10430735
Chest. 2018 Jan;153(1):217-223
pubmed: 28629920
Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1492-7
pubmed: 16432186
Chest. 2009 Feb;135(2):536-537
pubmed: 19201716
Clin Pharmacokinet. 2016 Dec;55(12):1495-1505
pubmed: 27286723
Mol Cancer Res. 2010 Apr;8(4):569-77
pubmed: 20353998
Br J Pharmacol. 2018 Feb;175(3):407-411
pubmed: 29350411
Thorax. 2014 Feb;69(2):123-9
pubmed: 24431095
Mol Endocrinol. 2009 Aug;23(8):1291-305
pubmed: 19407222
Life Sci. 2003 Dec 5;74(2-3):143-53
pubmed: 14607241
Br J Pharmacol. 1999 Feb;126(4):845-7
pubmed: 10193763
J Clin Med. 2016 Aug 26;5(9):
pubmed: 27571110
Respiration. 2010;79(5):377-82
pubmed: 19786728
Br J Pharmacol. 1999 Feb;126(4):867-72
pubmed: 10193766
Pulm Circ. 2015 Mar;5(1):162-70
pubmed: 25992279
Br J Pharmacol. 2017 Dec;174 Suppl 1:S17-S129
pubmed: 29055040
Am J Physiol Lung Cell Mol Physiol. 2009 Jan;296(1):L115-20
pubmed: 18952757
Pulm Pharmacol Ther. 2012 Feb;25(1):115-8
pubmed: 22244823
Eur J Pharmacol. 2011 May 20;659(1):72-8
pubmed: 21397595
J Heart Lung Transplant. 2011 Dec;30(12):1327-33
pubmed: 22055098
Trends Pharmacol Sci. 2017 Jun;38(6):512-523
pubmed: 28412042
Pharmacol Ther. 2004 May;102(2):139-53
pubmed: 15163595
J Am Coll Cardiol. 2010 May 4;55(18):1915-22
pubmed: 20430262
Prostaglandins Other Lipid Mediat. 2015 Jul;120:56-71
pubmed: 25917921