Effect of alpha-NETA on auditory event related potentials in sensory gating study paradigm in mice.
Alpha-NETA
Event related potentials
N40
Sensory gating
TAAR5
Journal
Neuroscience letters
ISSN: 1872-7972
Titre abrégé: Neurosci Lett
Pays: Ireland
ID NLM: 7600130
Informations de publication
Date de publication:
01 11 2019
01 11 2019
Historique:
received:
21
05
2019
revised:
01
08
2019
accepted:
29
08
2019
pubmed:
3
9
2019
medline:
24
9
2020
entrez:
3
9
2019
Statut:
ppublish
Résumé
The potential contribution of trace amines (TA) to the pathophysiology of neuropsychiatric disorders makes it interesting to examine the effect of TA receptor ligands on schizophrenia biomarkers. We studied the effect of systemic administration of a putative Trace Amine-Associated Receptor 5 (TAAR5) agonist, alpha-NETA (2-(alpha-naphthoyl) ethyltrimethylammonium iodide), on the amplitude of the N40 event related potentials component and on the sensory gating (SG) index in C57BL/6 mice. It was found that low doses of alpha-NETA (2.5 mg/kg and 5 mg/kg) do not elicit a significant effect on the parameters of the N40 component and the SG index. However, the higher dose of alpha-NETA (10 mg/kg) induces a significant effect on the N40 component, but since a decrease in amplitude is observed on both the first and second stimuli in the pair, the SG index does not change. Thus, alpha-NETA administration causes a steady decrease in the N40 amplitude in response to both the first and second stimuli in the paired-click paradigm, and an increase in the N40 peak latency.
Identifiants
pubmed: 31476355
pii: S0304-3940(19)30573-7
doi: 10.1016/j.neulet.2019.134470
pii:
doi:
Substances chimiques
Naphthalenes
0
Quaternary Ammonium Compounds
0
2-naphthoylethyltrimethylammonium
31059-54-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
134470Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.