Parental asthma occurrence, exacerbations and risk of attention-deficit/hyperactivity disorder.

Adolescent Adult Asthma / complications Attention Deficit Disorder with Hyperactivity / etiology Child Child, Preschool Cohort Studies Denmark Female Humans Male Maternal Exposure / adverse effects Maternal-Fetal Exchange / physiology Parents Pregnancy Prenatal Exposure Delayed Effects / immunology Proportional Hazards Models Registries Risk Factors
Asthma Attention-deficit/hyperactivity disorder Cohort studies Registries

Journal

Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478

Informations de publication

Date de publication:
11 2019
Historique:
received: 08 07 2019
revised: 19 08 2019
accepted: 29 08 2019
pubmed: 3 9 2019
medline: 17 9 2020
entrez: 3 9 2019
Statut: ppublish

Résumé

To investigate whether intrauterine exposure to maternal asthma or asthma exacerbations increases the risk of attention-deficit/hyperactivity disorder (ADHD). Using Danish register data, this cohort study comprised of 961,202 live singletons born in Denmark during 1997-2012. Children were followed to a maximum of 20.0 years from birth until the first of ADHD-diagnosis/prescription, emigration, death, or 31 December 2016. Cox regression models were used to evaluate the association between maternal or paternal asthma, asthma exacerbations and offspring ADHD. During 11.4 million person-years of follow-up, 27,780 (2.9%) children were identified as having ADHD. ADHD risk was increased among offspring born to asthmatic mothers (hazard ratio (HR) 1.41, 95% CI: 1.36-1.46) or asthmatic fathers (HR 1.13, 95% CI: 1.08-1.18). Antenatal antiasthma medication treatment did not increase offspring ADHD. However, higher risks were observed among offspring of mothers with asthma exacerbations compared with children of asthmatic mothers with no exacerbations: HR 1.12 (95% CI: 1.00-1.25) for pre-pregnancy exacerbations; 1.21 (95% CI: 1.00-1.47) for exacerbations during pregnancy; and 1.25 (95% CI: 1.08-1.44) for exacerbations after delivery. These results support theories regarding shared genetic and environmental risk factors having a role in the development of ADHD.

Identifiants

DOI: 10.1016/j.bbi.2019.08.198 PMID: 31476415 PMC: PMC7408292
pubmed: 31476415
pii: S0889-1591(19)30738-X
doi: 10.1016/j.bbi.2019.08.198
pmc: PMC7408292
mid: NIHMS1544291
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

302-308

Subventions

Organisme : NIEHS NIH HHS
ID : R01 ES026993
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD082078
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023337
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

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Auteurs

Xiaoqin Liu (X)

The National Centre for Register-based Research, Department of Economics and Business Economics, Business and Social Science, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark. Electronic address: lxq@econ.au.dk.

Søren Dalsgaard (S)

The National Centre for Register-based Research, Department of Economics and Business Economics, Business and Social Science, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; CIRRAU-The Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark; Department for Child and Adolescent Psychiatry, Hospital of Telemark, Kragerø, Norway.

Trine Munk-Olsen (T)

The National Centre for Register-based Research, Department of Economics and Business Economics, Business and Social Science, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.

Jiong Li (J)

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; Ministry of Education - Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, China.

Rosalind J Wright (RJ)

Department of Pediatrics, Kravis Children's Hospital, Icahn School of Medicine at Mount Sinai, NY, USA; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, NY, USA.

Natalie C Momen (NC)

The National Centre for Register-based Research, Department of Economics and Business Economics, Business and Social Science, Aarhus University, Aarhus, Denmark; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Parental asthma occurrence, exacerbations and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Parental asthma occurrence, exacerbations and...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Parental asthma occurrence, exacerbations and...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles déficitaires de l'attention et du comportement perturbateur › Trouble déficitaire de l'attention avec hyperactivité › Parental asthma occurrence, exacerbations and...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Parental asthma occurrence, exacerbations and...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Parental asthma occurrence, exacerbations and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Parental asthma occurrence, exacerbations and...
questionsmedicales.fr › Régions géographiques › Europe › Pays nordiques et scandinaves › Danemark › Parental asthma occurrence, exacerbations and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Parental asthma occurrence, exacerbations and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Exposition maternelle › Parental asthma occurrence, exacerbations and...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Échange foetomaternel › Parental asthma occurrence, exacerbations and...
questionsmedicales.fr › Personnes › Parents › Parental asthma occurrence, exacerbations and...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Parental asthma occurrence, exacerbations and...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Lésions prénatales › Effets différés de l'exposition prénatale à des facteurs de risque › Parental asthma occurrence, exacerbations and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Modèles des risques proportionnels › Parental asthma occurrence, exacerbations and...
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