Cingulum bundle abnormalities and risk for schizophrenia.
Adolescent
Adult
Cognitive Dysfunction
/ diagnostic imaging
Diffusion Tensor Imaging
Female
Humans
Limbic System
/ diagnostic imaging
Male
Myelin Sheath
/ pathology
Neural Pathways
/ diagnostic imaging
Psychotic Disorders
/ diagnostic imaging
Risk
Schizophrenia
/ diagnostic imaging
White Matter
/ diagnostic imaging
Young Adult
Cingulum bundle
Diffusion Tensor Imaging
Fractional anisotropy
High risk psychosis
Limbic system
Myelination
Journal
Schizophrenia research
ISSN: 1573-2509
Titre abrégé: Schizophr Res
Pays: Netherlands
ID NLM: 8804207
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
26
11
2018
revised:
22
07
2019
accepted:
15
08
2019
pubmed:
4
9
2019
medline:
20
1
2021
entrez:
4
9
2019
Statut:
ppublish
Résumé
The cingulum bundle (CB) is a major white matter fiber tract of the limbic system that underlies cingulate cortex, passing longitudinally over the corpus callosum. The connectivity of this white matter fiber tract plays a major role in emotional expression, attention, motivation, and working memory, all of which are affected in schizophrenia. Myelin related CB abnormalities have also been implicated in schizophrenia. The purpose of this study is to determine whether or not CB abnormalities are evident in individuals at clinical high risk (CHR) for psychosis, and whether or not cognitive deficits in the domains subserved by CB are related to its structural abnormalities. Diffusion Tensor Imaging (DTI) was performed on a 3 T magnet. DT tractography was used to evaluate CB in 20 individuals meeting CHR criteria (13 males/7 females) and 23 healthy controls (12 males/11 females) group matched on age, gender, parental socioeconomic status, education, and handedness. Fractional anisotropy (FA), a measure of white matter coherence and integrity, radial diffusivity (RD), thought to reflect myelin integrity, trace, a possible marker of atrophy, and axial diffusivity (AD), thought to reflect axonal integrity, were averaged over the entire tract and used to investigate CB abnormalities in individuals at CHR for psychosis compared with healthy controls. Significant group differences were found between individuals at CHR for psychosis and controls for FA (p = 0.028), RD (p = 0.03) and trace (p = 0.031), but not for AD (p = 0.09). We did not find any significant correlations between DTI measures and clinical symptoms. These findings suggest abnormalities (possibly myelin related) in the CB in individuals at CHR for psychosis.
Sections du résumé
BACKGROUND
The cingulum bundle (CB) is a major white matter fiber tract of the limbic system that underlies cingulate cortex, passing longitudinally over the corpus callosum. The connectivity of this white matter fiber tract plays a major role in emotional expression, attention, motivation, and working memory, all of which are affected in schizophrenia. Myelin related CB abnormalities have also been implicated in schizophrenia. The purpose of this study is to determine whether or not CB abnormalities are evident in individuals at clinical high risk (CHR) for psychosis, and whether or not cognitive deficits in the domains subserved by CB are related to its structural abnormalities.
METHODS
Diffusion Tensor Imaging (DTI) was performed on a 3 T magnet. DT tractography was used to evaluate CB in 20 individuals meeting CHR criteria (13 males/7 females) and 23 healthy controls (12 males/11 females) group matched on age, gender, parental socioeconomic status, education, and handedness. Fractional anisotropy (FA), a measure of white matter coherence and integrity, radial diffusivity (RD), thought to reflect myelin integrity, trace, a possible marker of atrophy, and axial diffusivity (AD), thought to reflect axonal integrity, were averaged over the entire tract and used to investigate CB abnormalities in individuals at CHR for psychosis compared with healthy controls.
RESULTS
Significant group differences were found between individuals at CHR for psychosis and controls for FA (p = 0.028), RD (p = 0.03) and trace (p = 0.031), but not for AD (p = 0.09). We did not find any significant correlations between DTI measures and clinical symptoms.
CONCLUSION
These findings suggest abnormalities (possibly myelin related) in the CB in individuals at CHR for psychosis.
Identifiants
pubmed: 31477373
pii: S0920-9964(19)30358-5
doi: 10.1016/j.schres.2019.08.017
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
385-391Subventions
Organisme : NIMH NIH HHS
ID : T32 MH016259
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH102377
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH050740
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH080272
Pays : United States
Organisme : NIMH NIH HHS
ID : K24 MH110807
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest All authors declare that they have no conflicts of interest.