Flexible 3D Cell-Based Platforms for the Discovery and Profiling of Novel Drugs Targeting

Animals Antimalarials / administration & dosage Drug Discovery / methods Female Humans Liver / parasitology Liver Diseases, Parasitic / drug therapy Malaria / drug therapy Male Mice Mice, Inbred BALB C Plasmodium berghei / drug effects Plasmodium falciparum / drug effects
3D cell models Plasmodium drug discovery in vitro liver stage infection malaria

Journal

ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580

Informations de publication

Date de publication:
08 11 2019
Historique:
pubmed: 4 9 2019
medline: 9 7 2020
entrez: 4 9 2019
Statut: ppublish

Résumé

The restricted pipeline of drugs targeting the liver stage of

Identifiants

DOI: 10.1021/acsinfecdis.9b00144 PMID: 31479238
pubmed: 31479238
doi: 10.1021/acsinfecdis.9b00144
doi:

Substances chimiques

Antimalarials 0

Types de publication

Evaluation Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1831-1842

Auteurs

Francisca Arez (F)

iBET , Instituto de Biologia Experimental e Tecnológica , Apartado 12 , 2780-901 Oeiras , Portugal.
Instituto de Tecnologia Química e Biológica António Xavier , Universidade Nova de Lisboa , Avenida da República , 2780-157 Oeiras , Portugal.

Sofia P Rebelo (SP)

iBET , Instituto de Biologia Experimental e Tecnológica , Apartado 12 , 2780-901 Oeiras , Portugal.
Instituto de Tecnologia Química e Biológica António Xavier , Universidade Nova de Lisboa , Avenida da República , 2780-157 Oeiras , Portugal.

Diana Fontinha (D)

Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina , Universidade de Lisboa , 1649-028 Lisboa , Portugal.

Daniel Simão (D)

iBET , Instituto de Biologia Experimental e Tecnológica , Apartado 12 , 2780-901 Oeiras , Portugal.
Instituto de Tecnologia Química e Biológica António Xavier , Universidade Nova de Lisboa , Avenida da República , 2780-157 Oeiras , Portugal.

Tatiana R Martins (TR)

iBET , Instituto de Biologia Experimental e Tecnológica , Apartado 12 , 2780-901 Oeiras , Portugal.
Instituto de Tecnologia Química e Biológica António Xavier , Universidade Nova de Lisboa , Avenida da República , 2780-157 Oeiras , Portugal.

Marta Machado (M)

Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina , Universidade de Lisboa , 1649-028 Lisboa , Portugal.

Christoph Fischli (C)

Swiss Tropical and Public Health Institute , Basel 4051 , Switzerland.
University of Basel , Basel 4003 , Switzerland.

Claude Oeuvray (C)

Global Health Institute of Merck , Ares Trading S.A., a subsidiary of Merck KGaA, Darmstadt, Germany , 1262 Eysins , Switzerland.

Lassina Badolo (L)

Discovery and Development Technologies , Merck Healthcare KGaA , Frankfurter Strasse 250 , 64293 Darmstadt , Germany.

Manuel J T Carrondo (MJT)

iBET , Instituto de Biologia Experimental e Tecnológica , Apartado 12 , 2780-901 Oeiras , Portugal.
Instituto de Tecnologia Química e Biológica António Xavier , Universidade Nova de Lisboa , Avenida da República , 2780-157 Oeiras , Portugal.

Matthias Rottmann (M)

Swiss Tropical and Public Health Institute , Basel 4051 , Switzerland.
University of Basel , Basel 4003 , Switzerland.

Thomas Spangenberg (T)

Global Health Institute of Merck , Ares Trading S.A., a subsidiary of Merck KGaA, Darmstadt, Germany , 1262 Eysins , Switzerland.
ORCID: 0000-0002-5654-8919

Catarina Brito (C)

iBET , Instituto de Biologia Experimental e Tecnológica , Apartado 12 , 2780-901 Oeiras , Portugal.
Instituto de Tecnologia Química e Biológica António Xavier , Universidade Nova de Lisboa , Avenida da República , 2780-157 Oeiras , Portugal.

Beatrice Greco (B)

Global Health Institute of Merck , Ares Trading S.A., a subsidiary of Merck KGaA, Darmstadt, Germany , 1262 Eysins , Switzerland.

Miguel Prudêncio (M)

Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina , Universidade de Lisboa , 1649-028 Lisboa , Portugal.

Paula M Alves (PM)

iBET , Instituto de Biologia Experimental e Tecnológica , Apartado 12 , 2780-901 Oeiras , Portugal.
Instituto de Tecnologia Química e Biológica António Xavier , Universidade Nova de Lisboa , Avenida da República , 2780-157 Oeiras , Portugal.
ORCID: 0000-0003-1445-3556

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Flexible 3D Cell-Based Platforms for the...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Antipaludiques › Flexible 3D Cell-Based Platforms for the...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Flexible 3D Cell-Based Platforms for the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Flexible 3D Cell-Based Platforms for the...
questionsmedicales.fr › Système digestif › Foie › Flexible 3D Cell-Based Platforms for the...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Parasitoses hépatiques › Flexible 3D Cell-Based Platforms for the...
questionsmedicales.fr › Infection › Maladies vectorielles › Paludisme › Flexible 3D Cell-Based Platforms for the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Flexible 3D Cell-Based Platforms for the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Flexible 3D Cell-Based Platforms for the...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium berghei › Flexible 3D Cell-Based Platforms for the...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium falciparum › Flexible 3D Cell-Based Platforms for the...