Estrogen-related receptor γ controls sterol regulatory element-binding protein-1c expression and alcoholic fatty liver.

Animals Cells, Cultured Fatty Liver, Alcoholic / genetics Hep G2 Cells Humans Male Mice, Inbred C57BL Receptors, Estrogen / analysis Sterol Regulatory Element Binding Protein 1 / analysis Transcriptional Activation Up-Regulation
Alcoholic fatty liver CB(1) receptor ERRγ Gene regulation Hepatic lipogenesis SREBP-1c

Journal

Biochimica et biophysica acta. Molecular and cell biology of lipids
ISSN: 1879-2618
Titre abrégé: Biochim Biophys Acta Mol Cell Biol Lipids
Pays: Netherlands
ID NLM: 101731727

Informations de publication

Date de publication:
12 2019
Historique:
received: 24 05 2019
revised: 22 08 2019
accepted: 28 08 2019
pubmed: 4 9 2019
medline: 28 2 2020
entrez: 4 9 2019
Statut: ppublish

Résumé

Although SREBP-1c regulates key enzymes required for hepatic de novo lipogenesis, the mechanisms underlying transcriptional regulation of SREBP-1c in pathogenesis of alcoholic fatty liver is still incompletely understood. In this study, we investigated the role of ERRγ in alcohol-mediated hepatic lipogenesis and examined the possibility to ameliorate alcoholic fatty liver through its inverse agonist. Hepatic ERRγ and SREBP-1c expression was increased by alcohol-mediated activation of CB

Identifiants

DOI: 10.1016/j.bbalip.2019.158521 PMID: 31479733
pubmed: 31479733
pii: S1388-1981(19)30171-4
doi: 10.1016/j.bbalip.2019.158521
pii:
doi:

Substances chimiques

Esrrg protein, mouse 0
Receptors, Estrogen 0
Sterol Regulatory Element Binding Protein 1 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

158521

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Don-Kyu Kim (DK)

Department of Molecular Biotechnology, Chonnam National University, Gwangju 61186, Republic of Korea.

Yong-Hoon Kim (YH)

Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea; University of Science and Technology (UST), Daejeon 34113, Republic of Korea.

Jae-Ho Lee (JH)

Department of Physiology, Keimyung University School of Medicine, Daegu 42601, Republic of Korea.

Yoon Seok Jung (YS)

National Creative Research Initiatives Center for Nuclear Receptor Signals, Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 61186, Republic of Korea.

Jina Kim (J)

New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea.

Rilu Feng (R)

Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim 105760, Germany.

Tae-Il Jeon (TI)

Department of Animal Science, College of Agriculture & Life Science, Chonnam National University, Gwangju 61186, Republic of Korea.

In-Kyu Lee (IK)

Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, Republic of Korea; Leading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu 41404, Republic of Korea.

Sung Jin Cho (SJ)

New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea; Leading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu 41404, Republic of Korea.

Seung-Soon Im (SS)

Department of Physiology, Keimyung University School of Medicine, Daegu 42601, Republic of Korea.

Steven Dooley (S)

Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim 105760, Germany.

Timothy F Osborne (TF)

Institute for Fundamental Biomedical Research, Departments of Medicine and Biological Chemistry, Johns Hopkins University School of Medicine, St. Petersburg, FL 33701, USA.

Chul-Ho Lee (CH)

Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea; University of Science and Technology (UST), Daejeon 34113, Republic of Korea. Electronic address: chullee@kribb.re.kr.

Hueng-Sik Choi (HS)

National Creative Research Initiatives Center for Nuclear Receptor Signals, Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 61186, Republic of Korea. Electronic address: hsc@chonnam.ac.kr.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Estrogen-related receptor γ controls sterol...
questionsmedicales.fr › Cellules › Cellules cultivées › Estrogen-related receptor γ controls sterol...
questionsmedicales.fr › Troubles dus à des produits chimiques › Troubles dus à l'abus d'alcool › Maladies alcooliques du foie › Stéatose hépatique alcoolique › Estrogen-related receptor γ controls sterol...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Cellules HepG2 › Estrogen-related receptor γ controls sterol...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Estrogen-related receptor γ controls sterol...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Estrogen-related receptor γ controls sterol...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs aux stéroïdes › Récepteurs des oestrogènes › Estrogen-related receptor γ controls sterol...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteurs de transcription à motifs basiques hélice-boucle-hélice et à glissière à leucines › Protéines de liaison à l'élément de régulation des stérols › Protéine-1 de liaison à l'élément de régulation des stérols › Estrogen-related receptor γ controls sterol...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Activation de la transcription › Estrogen-related receptor γ controls sterol...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation positive › Estrogen-related receptor γ controls sterol...