Altered Lipid Metabolism in Blood Mononuclear Cells of Psoriatic Patients Indicates Differential Changes in Psoriasis Vulgaris and Psoriatic Arthritis.
Adult
Arthritis, Psoriatic
/ blood
Eicosanoids
/ metabolism
Endocannabinoids
/ metabolism
Female
Humans
Inflammation Mediators
/ metabolism
Interleukins
/ metabolism
Leukocytes, Mononuclear
/ metabolism
Lipid Metabolism
Male
Oxidation-Reduction
Phospholipids
/ metabolism
Principal Component Analysis
Psoriasis
/ blood
eicosanoids
endocannabinoids
lipid mediators
lipid peroxidation products
psoriasis vulgaris
psoriatic arthritis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Aug 2019
30 Aug 2019
Historique:
received:
26
07
2019
revised:
23
08
2019
accepted:
28
08
2019
entrez:
5
9
2019
pubmed:
5
9
2019
medline:
22
1
2020
Statut:
epublish
Résumé
The aim of this study was to investigate possible stress-associated disturbances in lipid metabolism in mononuclear cells, mainly lymphocytes of patients with psoriasis vulgaris (Ps, n = 32) or with psoriatic arthritis (PsA, n = 16) in respect to the healthy volunteers (n = 16). The results showed disturbances in lipid metabolism of psoriatic patients reflected by different phospholipid profiles. The levels of non-enzymatic lipid metabolites associated with oxidative stress 8-isoprostaglandin F2α (8-isoPGF2α) and free 4-hydroxynonenal (4-HNE) were higher in PsA, although levels of 4-HNE-His adducts were higher in Ps. In the case of the enzymatic metabolism of lipids, enhanced levels of endocannabinoids were observed in both forms of psoriasis, while higher expression of their receptors and activities of phospholipases were detected only in Ps. Moreover, cyclooxygenase-1 (COX-1) activity was enhanced only in Ps, but cyclooxygenase-2 (COX-2) was enhanced both in Ps and PsA, generating higher levels of eicosanoids: prostaglandin E1 (PGE1), leukotriene B4 (LTB4), 13-hydroxyoctadecadienoic acid (13HODE), thromboxane B2 (TXB2). Surprisingly, some of major eicosanoids 15-d-PGJ
Identifiants
pubmed: 31480263
pii: ijms20174249
doi: 10.3390/ijms20174249
pmc: PMC6747546
pii:
doi:
Substances chimiques
Eicosanoids
0
Endocannabinoids
0
Inflammation Mediators
0
Interleukins
0
Phospholipids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Narodowe Centrum Nauki
ID : 2016/23/B/NZ7/02350
Organisme : Polish National Agency for Academic Exchange (NAWA)
ID : PPI/APM/2018/00015/U/001
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