Human cardiac myosin light chain 4 (MYL4) mosaic expression patterns vary by sex.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
03 09 2019
03 09 2019
Historique:
received:
16
05
2019
accepted:
21
08
2019
entrez:
5
9
2019
pubmed:
5
9
2019
medline:
30
10
2020
Statut:
epublish
Résumé
Sex disparities modulate cardiac function, although the proteins and mechanisms remain to be elucidated. We recently demonstrated a mosaic pattern of protein expression in the heart for over 100 proteins. Here we investigate one of these proteins, myosin light chain 4 (MYL4), which is important for contractile functions by increasing force production. We assayed the expression pattern of MYL4 across 756 ventricular myocardial samples from 668 individuals utilizing a semi-automated Cell Profiler method on five tissue microarrays (TMAs) of cardiac tissues across a diverse set of diseases. The percentage of MYL4 positive cells was significantly higher in male subjects independently across all five TMAs, regardless of disease state (p = 8.66e-15). Higher MYL4 expression was also modestly associated with hypertrophic cardiomyopathy (p = 6.3e-04). MYL4 expression did not associate with sudden cardiac death or other cardiomyopathies. This study demonstrates a new mosaic pattern of protein expression that underlies sex disparities in the human heart.
Identifiants
pubmed: 31481666
doi: 10.1038/s41598-019-49191-0
pii: 10.1038/s41598-019-49191-0
pmc: PMC6722118
doi:
Substances chimiques
MYL4 protein, human
0
Myosin Light Chains
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12681Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM007814
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA006973
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM130564
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137811
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL131573
Pays : United States
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