Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses.
Animals
Antineoplastic Agents
/ pharmacology
Apoptosis
/ drug effects
Carcinogenesis
/ drug effects
Cell Cycle
Disease Models, Animal
Disease Progression
Female
Gene Expression Regulation, Neoplastic
Leukemia, Myeloid, Acute
/ genetics
Lymphoma
/ genetics
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mutation
Proto-Oncogene Proteins c-mdm2
/ physiology
Tumor Cells, Cultured
Tumor Suppressor Protein p53
/ physiology
Mdm2
apoptosis
mutant p53
p53
tumor suppression
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
15 10 2019
15 10 2019
Historique:
received:
25
03
2019
revised:
30
07
2019
accepted:
05
08
2019
pubmed:
5
9
2019
medline:
7
1
2020
entrez:
5
9
2019
Statut:
ppublish
Résumé
Engineered p53 mutant mice are valuable tools for delineating p53 functions in tumor suppression and cancer therapy. Here, we have introduced the R178E mutation into the Trp53 gene of mice to specifically ablate the cooperative nature of p53 DNA binding. Trp53
Identifiants
pubmed: 31483066
doi: 10.15252/embj.2019102096
pmc: PMC6792016
doi:
Substances chimiques
Antineoplastic Agents
0
Trp53 protein, mouse
0
Tumor Suppressor Protein p53
0
Mdm2 protein, mouse
EC 2.3.2.27
Proto-Oncogene Proteins c-mdm2
EC 2.3.2.27
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e102096Subventions
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : STI 182/7-1
Pays : International
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : TI 1028/2-1
Pays : International
Organisme : Deutsche Krebshilfe
ID : 111250
Pays : International
Organisme : Deutsche Krebshilfe
ID : 111444
Pays : International
Organisme : Deutsche Krebshilfe
ID : 70112623
Pays : International
Organisme : Deutsche José Carreras Leukämie Stiftung e.V.
ID : 13/08
Pays : International
Organisme : Deutsche José Carreras Leukämie Stiftung e.V.
ID : 09 R/2018
Pays : International
Organisme : Bundesministerium für Bildung und Forschung
ID : 031L0063
Pays : International
Organisme : German Center for Lung Research
Pays : International
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 The Authors. Published under the terms of the CC BY 4.0 license.
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