Effect of Early and Late Interventions with Dietary Oils on Vascular and Neural Complications in a Type 2 Diabetic Rat Model.
Animals
Diabetes Mellitus, Experimental
/ chemically induced
Diabetes Mellitus, Type 2
/ chemically induced
Diabetic Angiopathies
/ diet therapy
Diabetic Neuropathies
/ diet therapy
Diet, High-Fat
Dietary Fats, Unsaturated
/ administration & dosage
Drug Administration Schedule
Fatty Liver
/ metabolism
Lipid Metabolism
/ drug effects
Male
Rats
Rats, Sprague-Dawley
Sciatic Nerve
/ drug effects
Streptozocin
Time Factors
Journal
Journal of diabetes research
ISSN: 2314-6753
Titre abrégé: J Diabetes Res
Pays: England
ID NLM: 101605237
Informations de publication
Date de publication:
2019
2019
Historique:
received:
19
03
2019
revised:
28
05
2019
accepted:
08
07
2019
entrez:
6
9
2019
pubmed:
6
9
2019
medline:
17
3
2020
Statut:
epublish
Résumé
Determine the effect of dietary oils enriched in different mono- or polyunsaturated fatty acids, i.e., olive oil (18 : 1, oleic acid), safflower oil (18 : 2 n-6, linoleic acid), flaxseed oil (18 : 3 n-3, alpha linolenic acid), evening primrose oil (18 : 3 n-6, gamma linolenic acid), or menhaden oil (20:5/22 : 6 n-3 eicosapentaenoic/docosahexaenoic acids), on vascular and neural complications in high-fat-fed low-dose streptozotocin-treated Sprague-Dawley rats, an animal model for late-stage type 2 diabetes. Rats were fed a high-fat diet (45% kcal as fat primarily derived from lard) for 8 weeks and then treated with a low dose of streptozotocin (30 mg/kg) in order to induce hyperglycemia. After an additional 8 (early intervention) or 20 (late intervention) weeks, the different groups of rats were fed diets with 1/2 of the kcal of fat derived from lard replaced by the different dietary oils. In addition, a control group fed a standard diet (4.25% kcal as fat) and a diabetic group maintained on the high-fat diet were maintained. The treatment period was approximately 16 weeks. The endpoints evaluated included vascular reactivity of epineurial arterioles, motor and sensory nerve conduction velocity, thermal and corneal sensitivity, and innervation of sensory nerves in the cornea and skin. Our findings show that menhaden and flaxseed oil provided the greatest benefit for correcting peripheral nerve damage caused by diabetes, whereas enriching the high-fat diet with menhaden oil provided the most benefit to acetylcholine-mediated vascular relaxation of epineurial arterioles of the sciatic nerve. Enriching the diets with fatty acids derived from the other oils provided none to partial improvements. These studies imply that long-chain n-6 and n-3 polyunsaturated fatty acids could be an effective treatment for diabetic peripheral neuropathy with n-3 polyunsaturated fatty acids derived from fish oil being the most effective.
Identifiants
pubmed: 31485451
doi: 10.1155/2019/5020465
pmc: PMC6702827
doi:
Substances chimiques
Dietary Fats, Unsaturated
0
Streptozocin
5W494URQ81
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5020465Subventions
Organisme : RRD VA
ID : I01 RX000889
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK107399
Pays : United States
Déclaration de conflit d'intérêts
The authors of this paper have no conflict of interest to report.
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