Population Impact Attributable to Modifiable Risk Factors for Hyperuricemia.
Adult
Aged
Alcohol Drinking
/ epidemiology
Body Mass Index
Diet
/ statistics & numerical data
Dietary Approaches To Stop Hypertension
/ statistics & numerical data
Diuretics
/ therapeutic use
Female
Humans
Hyperuricemia
/ epidemiology
Male
Middle Aged
Nutrition Surveys
Obesity
/ epidemiology
Overweight
/ epidemiology
Prevalence
Risk Factors
Risk Reduction Behavior
United States
/ epidemiology
Young Adult
Journal
Arthritis & rheumatology (Hoboken, N.J.)
ISSN: 2326-5205
Titre abrégé: Arthritis Rheumatol
Pays: United States
ID NLM: 101623795
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
07
03
2019
accepted:
30
07
2019
pubmed:
6
9
2019
medline:
18
3
2020
entrez:
6
9
2019
Statut:
ppublish
Résumé
To examine modifiable risk factors in relation to the presence of hyperuricemia and to estimate the proportion of hyperuricemia cases in the general population that could be prevented by risk factor modification, along with estimates of the variance explained. Using data obtained from 14,624 adults representative of the US civilian noninstitutionalized population, we calculated adjusted prevalence ratios for hyperuricemia, population attributable risks (PARs), and the variance explained according to the following 4 factors: body mass index (BMI; ≥25 kg/m BMI, alcohol intake, adherence to a DASH-style diet, and diuretic use were all associated with serum urate levels and the presence of hyperuricemia in a dose-dependent manner. The corresponding PARs of hyperuricemia cases for overweight/obesity (prevalence 60%), nonadherence to a DASH-style diet (prevalence 82%), alcohol use (prevalence 48%), and diuretic use (prevalence 8%) were 44% (95% confidence interval [95% CI] 41%, 48%), 9% (95% CI 3%, 16%), 8% (95% CI 5%, 11%), and 12% (95% CI 11%, 14%), respectively, whereas the corresponding variances explained were 8.9%, 0.1%, 0.5%, and 5.0%. Our simulation study showed the variance nearing 0% as exposure prevalence neared 100%. In this nationally representative study, 4 modifiable risk factors (BMI, the DASH diet, alcohol use, and diuretic use) could be used to individually account for a notable proportion of hyperuricemia cases. However, the corresponding serum urate variance explained by these risk factors was very small and paradoxically masked their high prevalences, providing real-life empirical evidence for its limitations in assessing common risk factors.
Identifiants
pubmed: 31486212
doi: 10.1002/art.41067
pmc: PMC6935419
mid: NIHMS1044495
doi:
Substances chimiques
Diuretics
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
157-165Subventions
Organisme : NIAMS NIH HHS
ID : T32 AR007258
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR065944
Pays : United States
Organisme : CIHR
Pays : Canada
Informations de copyright
© 2019, American College of Rheumatology.
Références
Rheumatology (Oxford). 2010 Aug;49(8):1461-5
pubmed: 20421215
Am J Epidemiol. 1986 Feb;123(2):203-8
pubmed: 3946370
Ann Rheum Dis. 2013 Nov;72(11):1868-73
pubmed: 23349133
Ann Rheum Dis. 1997 Jan;56(1):22-6
pubmed: 9059136
Int J Epidemiol. 2011 Apr;40(2):503-12
pubmed: 21247886
Ann Rheum Dis. 1994 Nov;53(11):759-62
pubmed: 7826138
JAMA. 2009 Jul 22;302(4):401-11
pubmed: 19622819
J Rheumatol. 2008 Sep;35(9):1859-64
pubmed: 18634142
Int J Epidemiol. 2001 Jun;30(3):427-32; discussion 433-4
pubmed: 11416056
BMJ. 2012 Jan 12;344:d8190
pubmed: 22240117
Lancet. 2011 Aug 27;378(9793):838-47
pubmed: 21872752
JAMA. 2017 Apr 18;317(15):1529-1530
pubmed: 28278326
Aust N Z J Med. 1973 Aug;3(4):410-2
pubmed: 4519128
Arch Intern Med. 2008 Apr 14;168(7):713-20
pubmed: 18413553
Adv Exp Med Biol. 1974;41:435-42
pubmed: 4832568
JAMA. 1991 Dec 4;266(21):3008-11
pubmed: 1820474
J Am Soc Nephrol. 2009 Oct;20(10):2253-9
pubmed: 19679672
Atherosclerosis. 2012 Aug;223(2):497-503
pubmed: 22749515
Am J Public Health. 1998 Jan;88(1):15-9
pubmed: 9584027
Arthritis Rheum. 2004 Dec 15;51(6):1023-9
pubmed: 15593346
Sci Rep. 2014 Jun 09;4:5227
pubmed: 24909660
J Am Diet Assoc. 1999 Aug;99(8 Suppl):S19-27
pubmed: 10450290
Eur J Epidemiol. 1995 Jun;11(3):275-81
pubmed: 7493659
Br Med J (Clin Res Ed). 1987 Aug 22;295(6596):457-61
pubmed: 3117170
N Engl J Med. 2004 Mar 11;350(11):1093-103
pubmed: 15014182
Ann Rheum Dis. 2017 Nov;76(11):1870-1882
pubmed: 28866649
Am J Clin Nutr. 1991 Mar;53(3):665-9
pubmed: 2000819
N Engl J Med. 2004 Mar 11;350(11):1071-3
pubmed: 15014177
N Engl J Med. 2001 Sep 13;345(11):790-7
pubmed: 11556298
BMJ. 2018 Oct 10;363:k3951
pubmed: 30305269
N Engl J Med. 2000 Jul 6;343(1):16-22
pubmed: 10882764
Bibl Nutr Dieta. 1973;(19):34-43
pubmed: 4600927
Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10338-42
pubmed: 19506252
Lancet. 2011 Aug 27;378(9793):815-25
pubmed: 21872750
Stat Methods Med Res. 2001 Jun;10(3):195-216
pubmed: 11446148
Arthritis Rheum. 2008 Jan 15;59(1):109-16
pubmed: 18163396
Diabete Metab. 1987 Jul;13(3 Pt 2):375-80
pubmed: 3308568
Ann Rheum Dis. 2000 Jul;59(7):539-43
pubmed: 10873964
J Chronic Dis. 1974 Sep;27(7-8):345-64
pubmed: 4436426
BMJ. 2008 Feb 9;336(7639):309-12
pubmed: 18244959
Ann Rheum Dis. 2010 Sep;69(9):1677-82
pubmed: 20472590
N Engl J Med. 1996 Feb 15;334(7):445-51
pubmed: 8552148
Ann Rheum Dis. 1974 May;33(3):276-80
pubmed: 4843132
Arthritis Rheum. 2011 Oct;63(10):3136-41
pubmed: 21800283
Nat Rev Rheumatol. 2015 Nov;11(11):649-62
pubmed: 26150127
Arthritis Rheum. 2008 Jan;58(1):26-35
pubmed: 18163497
J Rheumatol. 2006 Jul;33(7):1341-5
pubmed: 16758506
Am J Clin Nutr. 2004 Apr;79(4):537-43
pubmed: 15051594
Semin Arthritis Rheum. 2017 Feb;46(4):451-456
pubmed: 28040245
Int J Obes. 1986;10(4):255-64
pubmed: 3771090
Am J Epidemiol. 1988 Dec;128(6):1185-97
pubmed: 3057878
Am J Public Health. 2002 Feb;92(2):246-9
pubmed: 11818300
Am J Clin Nutr. 2008 May;87(5):1480-7
pubmed: 18469274
Prev Med Rep. 2016 Sep 28;4:525-531
pubmed: 27747149
Ann Rheum Dis. 2015 Apr;74(4):661-7
pubmed: 24431399
J Int Med Res. 1990 Mar-Apr;18(2):120-41
pubmed: 2340945
J Rheumatol. 2002 Nov;29(11):2403-6
pubmed: 12415600
PLoS One. 2012;7(6):e39321
pubmed: 22723994
JAMA. 2010 Nov 24;304(20):2270-8
pubmed: 21068145
J Rheumatol. 2002 Jul;29(7):1350-5
pubmed: 12136887
Arch Intern Med. 2008 Feb 11;168(3):308-14
pubmed: 18268173
Lancet. 1970 Dec 19;2(7686):1310-1
pubmed: 4098798
Lancet. 1967 Sep 9;2(7515):528-31
pubmed: 4166890
Lancet. 2017 Dec 16;390(10113):2627-2642
pubmed: 29029897
BMJ. 2017 May 9;357:j1794
pubmed: 28487277
Arthritis Rheumatol. 2016 Dec;68(12):3002-3009
pubmed: 27523583
Br J Rheumatol. 1984 Aug;23(3):203-9
pubmed: 6743968