Altered amygdala subregion-related circuits in treatment-naïve post-traumatic stress disorder comorbid with major depressive disorder.
Adolescent
Adult
Amygdala
/ physiopathology
China
/ epidemiology
Comorbidity
Depressive Disorder, Major
/ epidemiology
Female
Functional Neuroimaging
Gyrus Cinguli
/ physiopathology
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neural Pathways
/ physiopathology
Putamen
/ physiopathology
Stress Disorders, Post-Traumatic
/ epidemiology
Young Adult
Amygdala
Fear processing
Major depressive disorder
Post-traumatic stress disorder
Resting-state functional connectivity
Journal
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
ISSN: 1873-7862
Titre abrégé: Eur Neuropsychopharmacol
Pays: Netherlands
ID NLM: 9111390
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
10
04
2019
revised:
18
07
2019
accepted:
27
07
2019
pubmed:
7
9
2019
medline:
15
7
2020
entrez:
7
9
2019
Statut:
ppublish
Résumé
Individuals with both post-traumatic stress disorder and major depressive disorder (PTSD+MDD) often show greater social and occupational impairment and poorer treatment response than individuals with PTSD alone. Increasing evidence reveals that the amygdala, a brain region implicated in the pathophysiology of both of these conditions, is a complex of structurally and functionally heterogeneous nuclei. Quantifying the functional connectivity of two key amygdala subregions, the basolateral (BLA) and centromedial (CMA), in PTSD+MDD and PTSD-alone could advance our understanding of the neurocircuitry of these conditions. 18 patients with PTSD+MDD, 28 with PTSD-alone, and 50 trauma exposed healthy controls (TEHC), all from a cohort who survived the same large earthquake in China, underwent resting-state functional magnetic resonance imaging. Bilateral BLA and CMA functional connectivity (FC) maps were created using a seed-based approach for each participant. The analysis of covariance of FC was used to determine between-group differences. A significant interaction between amygdala subregion and diagnostic group suggested that differences in connectivity patterns between the two seeds were mediated by diagnosis. Post-hoc analyses revealed that PTSD+MDD patients showed weaker connectivity between right BLA and (a) left anterior cingulate cortex/supplementary motor area, and (b) bilateral putamen/pallidum, compared with PTSD-alone patients. Higher CMA connectivities left ACC/SMA were also observed in PTSD+MDD compared with PTSD-alone. An inverse relationship between the connectivity of right BLA with right putamen/pallidum and MDD symptoms was found in PTSD+MDD. These findings indicate a relationship between the neural pathophysiology of PTSD+MDD compared with PTSD-alone and TEHC and may inform future clinical interventions.
Identifiants
pubmed: 31488341
pii: S0924-977X(19)30550-4
doi: 10.1016/j.euroneuro.2019.07.238
pmc: PMC7434633
mid: NIHMS1615483
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1092-1101Subventions
Organisme : NIMH NIH HHS
ID : K01 MH108721
Pays : United States
Informations de copyright
Copyright © 2019. Published by Elsevier B.V.
Références
Neuroimage. 2009 Apr 1;45(2):614-26
pubmed: 19110061
J Psychiatr Res. 2014 Jan;48(1):47-55
pubmed: 24139810
Neuroinformatics. 2016 Jul;14(3):339-51
pubmed: 27075850
Lancet Psychiatry. 2016 May;3(5):472-80
pubmed: 27150382
Neuropsychopharmacology. 2010 Jan;35(1):192-216
pubmed: 19693001
Neuropsychopharmacology. 2014 Jan;39(2):351-9
pubmed: 23929546
Biol Mood Anxiety Disord. 2011 Nov 01;1(1):8
pubmed: 22738227
Br J Psychiatry. 2002 Aug;181:102-10
pubmed: 12151279
Neuron. 2008 Sep 25;59(6):1037-50
pubmed: 18817740
J Trauma Stress. 2013 Jun;26(3):299-309
pubmed: 23696449
Eur J Psychotraumatol. 2013 May 02;4:
pubmed: 23671761
Neurosci Biobehav Rev. 2012 Jan;36(1):479-501
pubmed: 21889953
J Affect Disord. 2011 Nov;134(1-3):272-9
pubmed: 21757239
JAMA Psychiatry. 2017 Apr 01;74(4):407-415
pubmed: 28273291
Psychiatry Res. 2007 Aug 15;155(3):265-9
pubmed: 17572075
Hum Brain Mapp. 2015 Feb;36(2):768-78
pubmed: 25332057
Arch Gen Psychiatry. 1995 Dec;52(12):1048-60
pubmed: 7492257
Front Neuroinform. 2018 Aug 21;12:54
pubmed: 30186131
Nat Rev Neurosci. 2011 Jul 06;12(8):467-77
pubmed: 21731066
Cell Mol Neurobiol. 2003 Oct;23(4-5):727-38
pubmed: 14514027
Neuron. 2005 Oct 20;48(2):175-87
pubmed: 16242399
Compr Psychiatry. 1996 Sep-Oct;37(5):336-46
pubmed: 8879908
Biol Psychiatry. 2010 Sep 1;68(5):433-41
pubmed: 20573339
J Clin Psychiatry. 2013 Mar;74(3):e212-8
pubmed: 23561242
J Neurosci. 2007 Feb 28;27(9):2349-56
pubmed: 17329432
Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4734-9
pubmed: 20176931
Anat Embryol (Berl). 2005 Dec;210(5-6):343-52
pubmed: 16208455
Trends Cogn Sci. 2011 Oct;15(10):483-506
pubmed: 21908230
Arch Gen Psychiatry. 2005 Jun;62(6):617-27
pubmed: 15939839
Depress Anxiety. 2017 Jul;34(7):641-650
pubmed: 28030757
Brain Connect. 2012;2(1):25-32
pubmed: 22432927
J Neurosci. 1997 May 15;17(10):3870-82
pubmed: 9133405
PLoS One. 2007 Mar 21;2(3):e307
pubmed: 17375193
Hum Brain Mapp. 2016 Mar;37(3):1120-35
pubmed: 26859310
Clin Neuropsychol. 2014;28(1):128-45
pubmed: 24354897
J Affect Disord. 2015 Mar 15;174:257-64
pubmed: 25527996
Cereb Cortex. 2017 Nov 1;27(11):5156-5169
pubmed: 27702810
J Affect Disord. 2008 Nov;111(1):13-20
pubmed: 18603301
Biol Psychiatry. 2004 Mar 15;55(6):578-87
pubmed: 15013826
Arch Gen Psychiatry. 2009 Dec;66(12):1361-72
pubmed: 19996041
Curr Biol. 2007 Oct 23;17(20):R868-74
pubmed: 17956742
Neuropsychopharmacology. 2015 Sep;40(10):2317-26
pubmed: 25790021
Neuroimage. 2013 Jan 1;64:240-56
pubmed: 22926292
Behav Brain Res. 2011 Oct 1;223(2):403-10
pubmed: 21536077
Neuropsychopharmacology. 2010 Jan;35(1):169-91
pubmed: 19625997
Psychiatr Serv. 2009 Dec;60(12):1612-7
pubmed: 19952151
J Trauma Stress. 2014 Dec;27(6):680-8
pubmed: 25470556
J Psychiatr Res. 2017 Nov;94:15-22
pubmed: 28633076
Am J Psychiatry. 2010 Jun;167(6):648-62
pubmed: 20231322
Trends Neurosci. 2012 Jan;35(1):24-35
pubmed: 21798604
Neuroimage. 2002 Jun;16(2):331-48
pubmed: 12030820
J Gen Intern Med. 2007 Jun;22(6):711-8
pubmed: 17503104
PLoS One. 2017 Jan 20;12(1):e0168239
pubmed: 28107446
J Psychiatry Neurosci. 2018 Jul;43(4):262-272
pubmed: 29947609
Biol Psychiatry. 1998 Dec 15;44(12):1229-38
pubmed: 9861466
Neuron. 2014 Jun 4;82(5):966-80
pubmed: 24908482
Neuroimage. 2012 Feb 1;59(3):2142-54
pubmed: 22019881
Neuroimage. 2006 Apr 1;30(2):452-61
pubmed: 16326115
Neuroimage. 2013 Aug 1;76:183-201
pubmed: 23499792
Neuroimage. 2001 Jun;13(6 Pt 1):1044-52
pubmed: 11352610
J Trauma Stress. 1995 Jan;8(1):75-90
pubmed: 7712061
Depress Anxiety. 2009;26(12):1151-7
pubmed: 19842171
J Clin Psychiatry. 2001;62 Suppl 17:16-22
pubmed: 11495091
Magn Reson Med. 1996 Mar;35(3):346-55
pubmed: 8699946
Front Psychiatry. 2011 Nov 14;2:62
pubmed: 22102841
Trends Cogn Sci. 2006 Jun;10(6):271-7
pubmed: 16697695
Nat Neurosci. 2016 Aug 26;19(9):1175-87
pubmed: 27571196