Rock-paper-scissors: Engineered population dynamics increase genetic stability.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
06 09 2019
06 09 2019
Historique:
received:
14
11
2018
accepted:
25
07
2019
entrez:
7
9
2019
pubmed:
7
9
2019
medline:
27
12
2019
Statut:
ppublish
Résumé
Advances in synthetic biology have led to an arsenal of proof-of-principle bacterial circuits that can be leveraged for applications ranging from therapeutics to bioproduction. A unifying challenge for most applications is the presence of selective pressures that lead to high mutation rates for engineered bacteria. A common strategy is to develop cloning technologies aimed at increasing the fixation time for deleterious mutations in single cells. We adopt a complementary approach that is guided by ecological interactions, whereby cyclical population control is engineered to stabilize the functionality of intracellular gene circuits. Three strains of
Identifiants
pubmed: 31488693
pii: 365/6457/1045
doi: 10.1126/science.aaw0542
pmc: PMC6988775
mid: NIHMS1052426
doi:
Substances chimiques
Anti-Bacterial Agents
0
Colicins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1045-1049Subventions
Organisme : NIGMS NIH HHS
ID : P50 GM085764
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM069811
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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