Foeniculum vulgare (Fennel) promotes functional recovery and ameliorates oxidative stress following a lesion to the sciatic nerve in mouse model.
Foeniculum vulgare
functional recovery
nerve regeneration
oxidative stress
peripheral nerve injury
Journal
Journal of food biochemistry
ISSN: 1745-4514
Titre abrégé: J Food Biochem
Pays: United States
ID NLM: 7706045
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
23
03
2019
revised:
16
05
2019
accepted:
21
06
2019
entrez:
7
9
2019
pubmed:
7
9
2019
medline:
18
9
2020
Statut:
ppublish
Résumé
Peripheral nerve injury is one of the major health concerns of the present era which can lead to the long-lasting disability and even demise. Currently, no effective and side effect free remedy exists and exploration of effective therapeutic strategies to regain functional outcome is a need of hour. In the present study, we used BALB/c mice (N = 14 age, 10-12 weeks & weight 32-34 g) that were divided into two groups: Normal chow (n = 7) and Fennel chow (n = 7) group. Here, we have explored the role of crude Foeniculum vulgare mill seeds in promoting functional recovery following a mechanical insult to the sciatic nerve by an oral administration of a crude dose of 500 mg/kg BW. The recovery of both sensory and motor functions was significantly (p > .05) accelerated in the treatment group, assessed by behavioral analyses alongside total antioxidant capacity increase. Conclusively, F. vulgare can be a potential therapeutic candidate for accelerating functional recovery after peripheral nerve injury. PRACTICAL APPLICATIONS: The outcomes of study have vital practical application both for scientists and consumers. The therapeutic role of phytochemicals on functional recovery has not been explored yet. This study will help figure out plant based regimen as booster for brain health and intervention against traumatic nerve injuries. Moreover, it may also attract the food and pharmaceutical industries to formulate cost effective therapeutic products. Likewise, it can prove instrumental for scientists for advance research on this aspect with more mechanistic targets.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12983Informations de copyright
© 2019 Wiley Periodicals, Inc.
Références
Albert-Puleo, M. (1980). Fennel and anise as estrogenic agents. Journal of Ethnopharmacology, 2(4), 337-344. https://doi.org/10.1016/S0378-8741(80)81015-4
Aziz, N., Rasul, A., Malik, S. A., Anwar, H., Imran, A., Razzaq, A., … Hussain, G. (2019). Supplementation of Cannabis sativa L. leaf powder accelerates functional recovery and ameliorates Haemoglobin level following an induced injury to sciatic nerve in mouse model. Pakistan Journal of Pharmaceutical Sciences., 32, 785-792.
Benga, A., Zor, F., Korkmaz, A., Marinescu, B., & Gorantla, V. (2017). The neurochemistry of peripheral nerve regeneration. Indian Journal of Plastic Surgery, 50, 5. https://doi.org/10.4103/ijps.IJPS_14_17
Bhatti, S. A., Shah, S. A., Ahmed, T., & Zahid, S. (2018). Neuroprotective effects of Foeniculum vulgare seeds extract on lead-induced neurotoxicity in mice brain. Drug and Chemical Toxicology, 41(4), 399-407. https://doi.org/10.1080/01480545.2018.1459669
Bowtell, J., & Kelly, V. (2019). Fruit-derived polyphenol supplementation for athlete recovery and performance. Sports Medicine, 49(1), 3-23. https://doi.org/10.1007/s40279-018-0998-x
Choi, E. M., & Hwang, J. K. (2004). Anti-inflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare. Fitoterapia, 75, 557-565. https://doi.org/10.1016/j.fitote.2004.05.005
Elfar, J. C., Jacobson, J. A., Puzas, J. E., Rosier, R. N., & Zuscik, M. J. (2008). Erythropoietin accelerates functional recovery after peripheral nerve injury. The Journal of Bone & Joint Surgery-A, 90, 1644-1653. https://doi.org/10.2106/JBJS.G.00557
Gerhke, S. A., Shibli, J. A., & Salles, M. B. (2015). Potential of the use of an antioxidant compound to promote peripheral nerve regeneration after injury. Neural Regeneration Research, 10(7), 1063-1064. https://doi.org/10.4103/1673-5374.160082
Halter, B., Gonzalez de Aguilar, J.-L., Rene, F., Petri, S., Fricker, B., Echaniz-Laguna, A., … Loeffler, J.-P. (2010). Oxidative stress in skeletal muscle stimulates early expression of Rad in a mouse model of amyotrophic lateral sclerosis. Free Radical Biology & Medicine, 48(7), 915-923. https://doi.org/10.1016/j.freeradbiomed.2010.01.014
Hoke, A., & Brushart, T. (2009). Challenges and opportunities for regeneration in the peripheral nervous system. Journal of Experimental Neurology, 223, 1-4. https://doi.org/10.1016/j.expneurol.2009.12.001
Hussain, G., Huang, J., Rasul, A., Anwar, H., Imran, A., Maqbool, J., … Sun, T. (2019). Putative roles of plant-derived tannins in neurodegenerative and neuropsychiatry disorders: An updated review. Molecules, 24(12), 2213. https://doi.org/10.3390/molecules24122213
Hussain, G., Rasul, A., Anwar, H., Aziz, N., Razzaq, A., Wei, W., … Li, X. (2018). Role of plant derived alkaloids and their mechanism in neurodegenerative disorders. International Journal of Biological Sciences, 14, 341-357. https://doi.org/10.7150/ijbs.23247
Hussain, G., Schmitt, F., Henriques, A., Lequeu, T., Rene, F., Bindler, F., … Loeffler, J.-P. (2013). Systemic down-regulation of delta-9 desaturase promotes muscle oxidative metabolism and accelerates muscle function recovery following nerve injury. PLoS ONE, 8(6), e64525. https://doi.org/10.1371/journal.pone.0064525
Hussain, G., Zhang, L., Rasul, A., Anwar, H., Sohail, M., Razzaq, A., … Sun, T. (2018). Role of plant-derived flavonoids and their mechanism in attenuation of Alzheimer’s and Parkinson’s diseases: An update of recent data. Molecules, 23(4), 1-26. https://doi.org/10.3390/molecules23040814
Joshi, H., & Parle, M. (2006). Cholinergic basis of memory-strengthening effect of Foeniculum vulgare Linn. Journal of Medicinal Foods, 9, 413-417. https://doi.org/10.1089/jmf.2006.9.413
Kooti, W., Moradi, M., Ali-akbari, S., Sharafi-ahvazi, N., Asadi-samani, M., & Mill, F. (2015). Therapeutic and pharmacological potential of Foeniculum vulgare Mill: A review. Journal of HerbMed Pharmacology, 4, 1-9.
Koppula, S., & Kumar, H. (2013). Foeniculum vulgare Mill (Umbelliferae) attenuates stress and improves memory in Wister rats. Tropical Journal of Pharmaceutical Research, 12, 553-558. https://doi.org/10.4314/tjpr.v12i4.17
Lee, J. Y., Choi, H. Y., Ju, B. G., & Yune, T. Y. (2018). Estrogen alleviates neuropathic pain induced after spinal cord injury by inhibiting microglia and astrocyte activation. Biochimica Et Biophysica Acta, 1864, 2472-2480.
Liu, R. H. (2003). Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. The American Journal of Clinical Nutrition, 48(3 Suppl), 517S-520S. https://doi.org/10.1093/ajcn/78.3.517S
Ma, J., Yu, H., Liu, J., Chen, Y., Wang, Q., & Xiang, L. (2016). Curcumin promotes nerve regeneration and functional recovery after sciatic nerve crush injury in diabetic rats. Neuroscience Letter, 610, 139-143. https://doi.org/10.1016/j.neulet.2015.11.005
Menéndez, L., Lastra, A., Hidalgo, A., & Baamonde, A. (2002). Unilateral hot plate test: A simple and sensitive method for detecting central and peripheral hyperalgesia in mice. Journal of Neuroscience Methods, 113, 91-97. https://doi.org/10.1016/S0165-0270(01)00483-6
Mhaidat, N. M., Abu-Zaiton, A. S., Alzoubi, K. H., Alzoubi, W., & Alazab, R. S. (2015). Antihyperglycemic properties of Foeniculum vulgare extract in streptozocin-induced diabetes in rats. International Journal of Pharmacology, 11, 72-75. https://doi.org/10.3923/ijp.2015.72.75
Moimas, S., Novati, F., Ronchi, G., Zacchigna, S., Fregnan, F., Zentilin, L., … Raimondo, S. (2013). Effect of vascular endothelial growth factor gene therapy on post-traumatic peripheral nerve regeneration and denervation-related muscle atrophy. Gene Therapy, 20, 1014-1021. https://doi.org/10.1038/gt.2013.26
Oktay, M., Gülçin, I., & Küfrevioğlu, Ö. İ. (2013). Determination of in vitro antioxidant activity of fennel (Foeniculum vulgare) seed extracts. LWT-Food Science and Technology, 36, 263-271. https://doi.org/10.1016/s0023-6438(02)00226-8
Plastaras, C. T., Chhatre, A., & Kotcharian, A. S. (2014). Perioperative lower extremity peripheral nerve traction injuries. Orthopedic Clinics of North America, 45(1), 55-63. https://doi.org/10.1016/j.ocl.2013.09.005
Rather, M. A., Dar, B. A., Sofi, S. N., Bhat, B. A., & Qurishi, M. A. (2016). Foeniculum vulgare: A comprehensive review of its traditional use, phytochemistry, pharmacology, and safety. Arabian Journal of Chemistry, 9, S1574-S1583. https://doi.org/10.1155/2014/842674
Richner, M., Ulrichsen, M., Elmegaard, S. L., Dieu, R., Pallesen, L. T., & Vaegter, C. B. (2014). Peripheral nerve injury modulates neurotrophin signaling in the peripheral and central nervous system. Molecular Neurobiology50(3), 945-970. https://doi.org/10.1007/s12035-014-8706-9
Rubio, C. P., Hernández-Ruiz, J., Martinez-Subiela, S., Tvarijonaviciute, A., & Ceron, J. J. (2016). Spectrophotometric assays for total antioxidant capacity (TAC) in dog serum: An update. BMC Veterinary Research, 12, 1-7. https://doi.org/10.1186/s12917-016-0792-7
Uriarte, P., & Calvo, M. I. (2009). Phytochemical study and evaluation of antioxidant, neuroprotective and acetylcholinesterase inhibitor activities of Galeopsis ladanum L. extracts. Pharmacognosy Magazine, 5, 287-290. https://doi.org/10.4103/0973-1296.58146
Wu, R., Feng, J., Yang, Y., Dai, C., Lu, A., Li, J., … Du, X.-B. (2017). Significance of serum total oxidant/antioxidant status in patients with colorectal cancer. PLoS ONE, 12(1), e0170003. https://doi.org/10.1371/journal.pone.0170003
Yang, I. J., Lee, D. U., & Shin, H. M. (2015). Anti-inflammatory and antioxidant effects of coumarins isolated from Foeniculum vulgare in lipopolysaccharide-stimulated macrophages and 12-O-tetradecanoylphorbol-13-acetate-stimulated mice. Immunopharmacology and Immunotoxicology, 37, 308-317. https://doi.org/10.3109/08923973.2015.1038751
Yu, L. U., Yang, F., Luo, H., Liu, F.-Y., Han, J.-S., Xing, G.-G., & Wan, Y. (2008). The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund’s adjuvant. Molecular Pain, 4, 61. https://doi.org/10.1186/1744-8069-4-61