Biochemical Characterization of a Multifunctional Mononuclear Nonheme Iron Enzyme (PtlD) in Neopentalenoketolactone Biosynthesis.

Lactones / chemistry Molecular Conformation Multifunctional Enzymes / metabolism Sesquiterpenes / chemistry Stereoisomerism Streptomyces / enzymology

Journal

Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393

Informations de publication

Date de publication:
20 09 2019
Historique:
pubmed: 7 9 2019
medline: 29 7 2020
entrez: 7 9 2019
Statut: ppublish

Résumé

Pentalenolactone is a microbial sesquiterpenoid with antibiotic activity. Its biosynthetic pathway was elucidated by a combination of genetic and biochemical characterizations of all genes involved. For the related neopentalenoketolactone biosynthetic gene cluster from

Identifiants

DOI: 10.1021/acs.orglett.9b02872 PMID: 31490082
pubmed: 31490082
doi: 10.1021/acs.orglett.9b02872
doi:

Substances chimiques

Lactones 0
Multifunctional Enzymes 0
Sesquiterpenes 0
neopentalenoketolactone 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

7592-7596

Auteurs

Qian Deng (Q)

Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, School of Pharmaceutical Sciences , Wuhan University , Hubei 430072 , People's Republic of China.

Yang Liu (Y)

Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, School of Pharmaceutical Sciences , Wuhan University , Hubei 430072 , People's Republic of China.

Linyue Chen (L)

Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, School of Pharmaceutical Sciences , Wuhan University , Hubei 430072 , People's Republic of China.

Meiling Xu (M)

Department of Chemistry , Boston University , 590 Commonwealth Avenue , Boston , Massachusetts 02215 , United States.

Nathchar Naowarojna (N)

Department of Chemistry , Boston University , 590 Commonwealth Avenue , Boston , Massachusetts 02215 , United States.

Norman Lee (N)

Department of Chemistry , Boston University , 590 Commonwealth Avenue , Boston , Massachusetts 02215 , United States.

Li Chen (L)

Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, School of Pharmaceutical Sciences , Wuhan University , Hubei 430072 , People's Republic of China.
Department of Chemistry , Boston University , 590 Commonwealth Avenue , Boston , Massachusetts 02215 , United States.

Dongqing Zhu (D)

Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, School of Pharmaceutical Sciences , Wuhan University , Hubei 430072 , People's Republic of China.
ORCID: 0000-0002-6298-512X

Xuechuan Hong (X)

Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, School of Pharmaceutical Sciences , Wuhan University , Hubei 430072 , People's Republic of China.

Zixin Deng (Z)

Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, School of Pharmaceutical Sciences , Wuhan University , Hubei 430072 , People's Republic of China.

Pinghua Liu (P)

Department of Chemistry , Boston University , 590 Commonwealth Avenue , Boston , Massachusetts 02215 , United States.
ORCID: 0000-0002-9768-559X

Changming Zhao (C)

Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, School of Pharmaceutical Sciences , Wuhan University , Hubei 430072 , People's Republic of China.
ORCID: 0000-0002-8283-9621

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Lactones › Biochemical Characterization of a...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Biochemical Characterization of a...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Enzymes multifonctionnelles › Biochemical Characterization of a...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Sesquiterpènes › Biochemical Characterization of a...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Stéréoisomérie › Biochemical Characterization of a...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets sporulés à Gram positif › Streptomycetaceae › Streptomyces › Biochemical Characterization of a...