RNA-Based Detection of Gene Fusions in Formalin-Fixed and Paraffin-Embedded Solid Cancer Samples.

NGS carcinoma gene fusion solid tumor targeted therapy

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
05 Sep 2019
Historique:
received: 13 08 2019
accepted: 27 08 2019
entrez: 8 9 2019
pubmed: 8 9 2019
medline: 8 9 2019
Statut: epublish

Résumé

Oncogenic gene fusions are important drivers in many cancer types, including carcinomas, with diagnostic and therapeutic implications. Hence, sensitive and rapid methods for parallel profiling in formalin-fixed and paraffin-embedded (FFPE) specimens are needed. In this study we analyzed gene fusions in a cohort of 517 cases where standard treatment options were exhausted. To this end the Archer

Identifiants

pubmed: 31491926
pii: cancers11091309
doi: 10.3390/cancers11091309
pmc: PMC6769558
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Martina Kirchner (M)

Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Olaf Neumann (O)

Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Anna-Lena Volckmar (AL)

Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Fabian Stögbauer (F)

Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Michael Allgäuer (M)

Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Daniel Kazdal (D)

Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Jan Budczies (J)

Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
German Cancer Consortium (DKTK), 69120 Heidelberg partner sites, Germany.

Eugen Rempel (E)

Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Regine Brandt (R)

Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Suranand Babu Talla (SB)

Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Moritz von Winterfeld (M)

Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Jonas Leichsenring (J)

Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Tilmann Bochtler (T)

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Department of Internal Medicine V, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Alwin Krämer (A)

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Department of Internal Medicine V, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Christoph Springfeld (C)

Department of Internal Medicine VI, University Hospital Heidelberg, 69120 Heidelberg, Germany.
National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany.

Peter Schirmacher (P)

Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
German Cancer Consortium (DKTK), 69120 Heidelberg partner sites, Germany.

Roland Penzel (R)

Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Volker Endris (V)

Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Albrecht Stenzinger (A)

Institute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany. albrecht.stenzinger@med.uni-heidelberg.de.
German Cancer Consortium (DKTK), 69120 Heidelberg partner sites, Germany. albrecht.stenzinger@med.uni-heidelberg.de.

Classifications MeSH