Fluid pumping and active flexoelectricity can promote lumen nucleation in cell assemblies.
continuum theory of tissues
lumen formation
tissue biophysics
tissue flexoelectricity
tissue hydraulics
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
24 09 2019
24 09 2019
Historique:
pmc-release:
06
03
2020
pubmed:
8
9
2019
medline:
3
4
2020
entrez:
8
9
2019
Statut:
ppublish
Résumé
We discuss the physical mechanisms that promote or suppress the nucleation of a fluid-filled lumen inside a cell assembly or a tissue. We discuss lumen formation in a continuum theory of tissue material properties in which the tissue is described as a 2-fluid system to account for its permeation by the interstitial fluid, and we include fluid pumping as well as active electric effects. Considering a spherical geometry and a polarized tissue, our work shows that fluid pumping and tissue flexoelectricity play a crucial role in lumen formation. We furthermore explore the large variety of long-time states that are accessible for the cell aggregate and its lumen. Our work reveals a role of the coupling of mechanical, electrical, and hydraulic phenomena in tissue lumen formation.
Identifiants
pubmed: 31492815
pii: 1908481116
doi: 10.1073/pnas.1908481116
pmc: PMC6765252
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
19264-19273Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Nature. 2019 Jul;571(7763):112-116
pubmed: 31189957
Sci Rep. 2018 Jul 10;8(1):10391
pubmed: 29991812
J Cell Sci. 2008 Nov 1;121(Pt 21):3649-63
pubmed: 18946028
Phys Rev Lett. 2000 Apr 10;84(15):3494-7
pubmed: 11019123
J Membr Biol. 2002 May 1;187(1):37-50
pubmed: 12029376
Development. 2017 Mar 15;144(6):976-985
pubmed: 28292844
J Physiol. 1972 Feb;221(1):43-54
pubmed: 5016991
Cell. 2002 Oct 4;111(1):29-40
pubmed: 12372298
Nat Rev Mol Cell Biol. 2002 Jul;3(7):531-7
pubmed: 12094219
Phys Rev Lett. 2013 Mar 29;110(13):138103
pubmed: 23581378
Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):20863-8
pubmed: 21078958
Development. 2017 Dec 1;144(23):4422-4427
pubmed: 29183945
Curr Biol. 2008 Apr 8;18(7):507-13
pubmed: 18394894
Cell. 2003 Jan 10;112(1):19-28
pubmed: 12526790
Interface Focus. 2014 Dec 6;4(6):20140033
pubmed: 25485084
J Membr Biol. 2017 Jun;250(3):327-333
pubmed: 28623474
Ground Water. 2005 May-Jun;43(3):457-60
pubmed: 15882338
HFSP J. 2009 Aug;3(4):265-72
pubmed: 20119483
Bioelectrochemistry. 2018 Oct;123:45-61
pubmed: 29723806
Science. 2019 Aug 2;365(6452):465-468
pubmed: 31371608
Curr Biol. 2011 Feb 8;21(3):R126-36
pubmed: 21300279
Biosystems. 2018 Feb;164:76-93
pubmed: 28855098
Chem Soc Rev. 2019 Jun 4;48(11):3102-3144
pubmed: 31114820
Science. 2014 Jul 18;345(6194):1247125
pubmed: 25035496
Nat Rev Mol Cell Biol. 2014 Oct;15(10):665-76
pubmed: 25186133
J Cell Biol. 1978 Jun;77(3):853-80
pubmed: 567227
J Appl Physiol. 1968 Apr;24(4):602-5
pubmed: 5643415
Thorax. 1985 Jul;40(7):493-6
pubmed: 4035615
J Gen Physiol. 1979 Aug;74(2):213-36
pubmed: 39970
Biophys J. 1998 May;74(5):2227-34
pubmed: 9591650
Phys Rev Lett. 2011 Oct 28;107(18):188102
pubmed: 22107677
Cell Cycle. 2009 Nov 1;8(21):3527-36
pubmed: 19823012
Dev Biol. 2010 May 1;341(1):34-55
pubmed: 19778532
Cancer Res. 2000 May 1;60(9):2497-503
pubmed: 10811131
Eur Phys J E Soft Matter. 2012 Jun;35(6):46
pubmed: 22699388
Proc Natl Acad Sci U S A. 2018 May 22;115(21):E4751-E4757
pubmed: 29735699