An integrative approach to cisplatin chronic toxicities in mice reveals importance of organic cation-transporter-dependent protein networks for renoprotection.
Animals
Antineoplastic Agents
/ administration & dosage
Cisplatin
/ administration & dosage
Kidney Diseases
/ chemically induced
Male
Mice
Mice, Knockout
Neurotoxicity Syndromes
/ etiology
Octamer Transcription Factor-1
/ genetics
Organic Cation Transporter 2
/ genetics
Ototoxicity
/ etiology
Proteomics
Signal Transduction
/ drug effects
Cisplatin
Mouse model
Toxicities
Transporters
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
08
07
2019
accepted:
02
09
2019
pubmed:
8
9
2019
medline:
29
8
2020
entrez:
8
9
2019
Statut:
ppublish
Résumé
Cisplatin (CDDP) is one of the most important chemotherapeutic drugs in modern oncology. However, its use is limited by severe toxicities, which impair life quality after cancer. Here, we investigated the role of organic cation transporters (OCT) in mediating toxicities associated with chronic (twice the week for 4 weeks) low-dose (4 mg/kg body weight) CDDP treatment (resembling therapeutic protocols in patients) of wild-type (WT) mice and mice with OCT genetic deletion (OCT1/2
Identifiants
pubmed: 31493026
doi: 10.1007/s00204-019-02557-9
pii: 10.1007/s00204-019-02557-9
doi:
Substances chimiques
Antineoplastic Agents
0
Octamer Transcription Factor-1
0
Organic Cation Transporter 2
0
Pou2f1 protein, mouse
0
Slc22a2 protein, mouse
0
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2835-2848Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : 107/11-1
Pays : International
Organisme : NIH HHS
ID : R01CA215802
Pays : United States
Organisme : Fondazione Banca del Monte di Lombardia
ID : Paola Marmiroli
Pays : International
Organisme : NIH HHS
ID : R01CA215802
Pays : United States