Systemic biomarkers of inflammation, oxidative stress and tissue injury and repair among waterpipe, cigarette and dual tobacco smokers.
biomarkers
cigarette smokers
hookah
inflammation
oxidative stress
waterpipe
Journal
Tobacco control
ISSN: 1468-3318
Titre abrégé: Tob Control
Pays: England
ID NLM: 9209612
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
22
01
2019
revised:
07
06
2019
accepted:
10
06
2019
pubmed:
9
9
2019
medline:
3
6
2021
entrez:
9
9
2019
Statut:
ppublish
Résumé
Waterpipe tobacco (WPT) smoking is associated with deleterious effects on cardio-pulmonary systems which may have adverse repercussions in pathophysiology and progression of chronic lung and cardiovascular diseases. We compared the biomarkers of systemic inflammation, lipid mediators, injury/repair and oxidative stress between groups of non-smokers (NS), exclusive WPT smokers (WPS), exclusive cigarette smokers (CS) and dual WPS and CS (DS). Two cohorts were recruited. Cohort I consisted of WPS (n=12), CS (n=26), DS (n=10) and NS (n=25). Cohort II consisted of WPS (n=33) and NS (n=24). Plasma and urine samples were collected and analysed for various systemic biomarkers. Compared with NS, plasma levels of inflammatory mediators (interleukin (IL)-6, IL-8, IL1β and tumor necrosis factor-α) were significantly higher in WPS and CS, and were further augmented in DS. Endothelial biomarkers (intracellular adhesion molecule-1, prostaglandin E-2 and metalloproteinase-9) were significantly higher in CS. Most notably, pro-resolving lipid mediator (resolvin E1) and biomarkers of immunity, tissue injury, and repair were significantly lower in WPS and CS. Urinary levels of 8-isoprostane were significantly higher in all smoking groups in cohort I, while 8-isoprostane, myeloperoxidase, receptor for advanced glycation end products (RAGE), En-RAGE and matrix metalloproteinase-9 were significantly higher in all smoking groups in cohort II. Biomarkers of inflammation, oxidative stress, immunity, tissue injury and repair were elevated in WPS and CS groups. Furthermore, concurrent use of WPT and cigarettes is more harmful than cigarette or WPT smoking alone. These data may help inform the public and policy-makers about the dangers of WPT smoking and dual use of tobacco products.
Sections du résumé
BACKGROUND
Waterpipe tobacco (WPT) smoking is associated with deleterious effects on cardio-pulmonary systems which may have adverse repercussions in pathophysiology and progression of chronic lung and cardiovascular diseases. We compared the biomarkers of systemic inflammation, lipid mediators, injury/repair and oxidative stress between groups of non-smokers (NS), exclusive WPT smokers (WPS), exclusive cigarette smokers (CS) and dual WPS and CS (DS).
METHODS
Two cohorts were recruited. Cohort I consisted of WPS (n=12), CS (n=26), DS (n=10) and NS (n=25). Cohort II consisted of WPS (n=33) and NS (n=24). Plasma and urine samples were collected and analysed for various systemic biomarkers.
RESULTS
Compared with NS, plasma levels of inflammatory mediators (interleukin (IL)-6, IL-8, IL1β and tumor necrosis factor-α) were significantly higher in WPS and CS, and were further augmented in DS. Endothelial biomarkers (intracellular adhesion molecule-1, prostaglandin E-2 and metalloproteinase-9) were significantly higher in CS. Most notably, pro-resolving lipid mediator (resolvin E1) and biomarkers of immunity, tissue injury, and repair were significantly lower in WPS and CS. Urinary levels of 8-isoprostane were significantly higher in all smoking groups in cohort I, while 8-isoprostane, myeloperoxidase, receptor for advanced glycation end products (RAGE), En-RAGE and matrix metalloproteinase-9 were significantly higher in all smoking groups in cohort II.
CONCLUSIONS
Biomarkers of inflammation, oxidative stress, immunity, tissue injury and repair were elevated in WPS and CS groups. Furthermore, concurrent use of WPT and cigarettes is more harmful than cigarette or WPT smoking alone. These data may help inform the public and policy-makers about the dangers of WPT smoking and dual use of tobacco products.
Identifiants
pubmed: 31494573
pii: tobaccocontrol-2019-054958
doi: 10.1136/tobaccocontrol-2019-054958
pmc: PMC7050420
mid: NIHMS1052039
doi:
Substances chimiques
Biomarkers
0
Inflammation Mediators
0
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
s102-s109Subventions
Organisme : NIDA NIH HHS
ID : R01 DA042470
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA042471
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL085613
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL135613
Pays : United States
Informations de copyright
© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Rheumatology (Oxford). 2009 Oct;48(10):1190-6
pubmed: 19589888
Chron Respir Dis. 2018 May;15(2):165-172
pubmed: 28534421
Tob Control. 2015 May;24(3):290-7
pubmed: 24128428
COPD. 2016 Dec;13(6):756-759
pubmed: 27073968
Evid Based Dent. 2011;12(2):44-5
pubmed: 21701545
Inhal Toxicol. 2017 Aug;29(9):389-396
pubmed: 29039225
Int J Epidemiol. 2017 Feb 1;46(1):32-43
pubmed: 27075769
Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2695-9
pubmed: 25341801
J Transl Med. 2009 Mar 17;7:17
pubmed: 19292913
Ann N Y Acad Sci. 2000;923:68-77
pubmed: 11193780
Lung. 2008 Nov-Dec;186(6):403-9
pubmed: 18807087
ScientificWorldJournal. 2007 Oct 22;7:1691-6
pubmed: 17982564
PLoS One. 2016 Sep 26;11(9):e0163192
pubmed: 27669518
Toxicol Rep. 2018 Nov 20;6:18-25
pubmed: 30519530
Tanaffos. 2016;15(3):180-186
pubmed: 28210284
Atmos Environ (1994). 2010 Jan 1;44(1):8-14
pubmed: 20161525
Respir Res. 2010 May 25;11:63
pubmed: 20500811
Thorax. 2007 Jul;62(7):595-601
pubmed: 17356059
Environ Toxicol Pharmacol. 2018 Jul;61:38-43
pubmed: 29843053
Neth Heart J. 2014 Mar;22(3):91-9
pubmed: 24307377
Biochem Pharmacol. 2010 May 15;79(10):1379-86
pubmed: 20096667
Respir Med. 2004 Jun;98(6):551-6
pubmed: 15191041
Curr Med Chem. 2010;17(21):2232-52
pubmed: 20459381
Antioxid Redox Signal. 2013 May 20;18(15):1956-71
pubmed: 22978694
J Periodontol. 2016 Feb;87(2):142-7
pubmed: 26430928
Biochem Cell Biol. 2015 Dec;93(6):541-7
pubmed: 26291981
Tob Control. 2015 Mar;24 Suppl 1:i3-i12
pubmed: 25298368
Tob Control. 2015 Mar;24 Suppl 1:i31-i43
pubmed: 25661414
Physiol Rep. 2018 Feb;6(3):
pubmed: 29417753
Thorax. 2006 Jan;61(1):23-8
pubmed: 16143583
Cancer Epidemiol Biomarkers Prev. 2014 Dec;23(12):2793-809
pubmed: 25416714
Eur J Heart Fail. 2009 Sep;11(9):811-7
pubmed: 19648160
Chest. 2011 Apr;139(4):764-774
pubmed: 20671057
Thromb Haemost. 2000 Aug;84(2):210-5
pubmed: 10959691
Tob Control. 2020 Feb;29(Suppl 2):s123-s130
pubmed: 31326957
Circulation. 2019 May 7;139(19):e917-e936
pubmed: 30845826
Am J Respir Cell Mol Biol. 1997 Aug;17(2):141-3
pubmed: 9271300
Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):577-83
pubmed: 17372255