Plasma metabolites associated with colorectal cancer stage: Findings from an international consortium.
colorectal cancer
disease stage
epidemiology
metabolomics
plasma metabolites
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
15 06 2020
15 06 2020
Historique:
received:
11
03
2019
revised:
06
07
2019
accepted:
26
07
2019
pubmed:
10
9
2019
medline:
9
3
2021
entrez:
10
9
2019
Statut:
ppublish
Résumé
Colorectal cancer is the second most common cause of cancer-related death globally, with marked differences in prognosis by disease stage at diagnosis. We studied circulating metabolites in relation to disease stage to improve the understanding of metabolic pathways related to colorectal cancer progression. We investigated plasma concentrations of 130 metabolites among 744 Stages I-IV colorectal cancer patients from ongoing cohort studies. Plasma samples, collected at diagnosis, were analyzed with liquid chromatography-mass spectrometry using the Biocrates AbsoluteIDQ™ p180 kit. We assessed associations between metabolite concentrations and stage using multinomial and multivariable logistic regression models. Analyses were adjusted for potential confounders as well as multiple testing using false discovery rate (FDR) correction. Patients presented with 23, 28, 39 and 10% of Stages I-IV disease, respectively. Concentrations of sphingomyelin C26:0 were lower in Stage III patients compared to Stage I patients (p
Identifiants
pubmed: 31495913
doi: 10.1002/ijc.32666
pmc: PMC7216900
doi:
Substances chimiques
Biomarkers, Tumor
0
Sphingomyelins
0
Citrulline
29VT07BGDA
Histidine
4QD397987E
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3256-3266Subventions
Organisme : NCI NIH HHS
ID : R01 CA207371
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG008962
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA206110
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA189184
Pays : United States
Informations de copyright
© 2019 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.
Références
CA Cancer J Clin. 2014 Mar-Apr;64(2):104-17
pubmed: 24639052
Anal Bioanal Chem. 2013 Jun;405(15):5013-30
pubmed: 23494270
Am J Clin Nutr. 2014 Jul;100(1):208-17
pubmed: 24740205
Mol Cancer. 2008 Sep 18;7:72
pubmed: 18799019
Acta Biochim Pol. 2014;61(4):615-31
pubmed: 25473654
Iran J Basic Med Sci. 2017 Jul;20(7):835-840
pubmed: 28852450
Br J Cancer. 2019 Jan;120(2):238-246
pubmed: 30563990
Anal Chem. 2017 Jan 3;89(1):656-665
pubmed: 27959516
BMC Cancer. 2014 May 27;14:374
pubmed: 24886284
PLoS One. 2012;7(7):e40459
pubmed: 22792336
Cancer Metab. 2016 Jun 06;4:11
pubmed: 27275383
Cancer Epidemiol Biomarkers Prev. 2019 Mar;28(3):591-601
pubmed: 30523039
Int J Biol Sci. 2016 Jul 17;12(8):1022-31
pubmed: 27489505
Nutrients. 2018 May 22;10(5):
pubmed: 29789452
BMJ. 2003 Sep 6;327(7414):557-60
pubmed: 12958120
Aging Cell. 2012 Dec;11(6):960-7
pubmed: 22834969
Control Clin Trials. 1986 Sep;7(3):177-88
pubmed: 3802833
Metabolomics. 2015 Aug;11(4):998-1012
pubmed: 29250455
Stat Med. 2002 Jun 15;21(11):1539-58
pubmed: 12111919
Int J Cancer. 2019 Sep 1;145(5):1221-1231
pubmed: 30665271
Cancer Epidemiol Biomarkers Prev. 2013 Apr;22(4):631-40
pubmed: 23396963
Br J Cancer. 2016 Sep 27;115(7):848-57
pubmed: 27560555
Am J Clin Nutr. 2007 Jan;85(1):167-72
pubmed: 17209193
PLoS One. 2015 Aug 14;10(8):e0135437
pubmed: 26274920
Genome Med. 2012 May 14;4(5):42
pubmed: 22583555
Colorectal Dis. 2009 Feb;11(2):157-61
pubmed: 18462239
Metabolites. 2016 Mar 02;6(1):
pubmed: 26950159
Cancer Epidemiol Biomarkers Prev. 2018 May;27(5):531-540
pubmed: 29563134
Cancer Epidemiol Biomarkers Prev. 2014 Jul;23(7):1394-405
pubmed: 24802740
Brief Bioinform. 2017 May 1;18(3):498-510
pubmed: 27075479
Transl Psychiatry. 2013 Jul 02;3:e276
pubmed: 23820610