Exosomal HSP70 for Monitoring of Frontotemporal Dementia and Alzheimer's Disease: Clinical and FDG-PET Correlation.
Aged
Alzheimer Disease
/ blood
Biomarkers
/ blood
Correlation of Data
Exosomes
/ metabolism
Female
Fluorodeoxyglucose F18
/ pharmacology
Frontotemporal Dementia
/ blood
HSP70 Heat-Shock Proteins
/ blood
Humans
Male
Neuropsychological Tests
Positron-Emission Tomography
/ methods
Radiopharmaceuticals
/ pharmacology
Alzheimer’s disease
PET
biomarkers
exosomes
frontotemporal dementia
Journal
Journal of Alzheimer's disease : JAD
ISSN: 1875-8908
Titre abrégé: J Alzheimers Dis
Pays: Netherlands
ID NLM: 9814863
Informations de publication
Date de publication:
2019
2019
Historique:
pubmed:
10
9
2019
medline:
11
11
2020
entrez:
10
9
2019
Statut:
ppublish
Résumé
We aimed to study the expression of circulating heat-shock protein HSP70 and exosomes in plasma of a cohort of patients with Alzheimer's disease (AD) and frontotemporal dementia (FTD) at different stages. We performed correlations with clinical scales and FDG-PET. HSP70 levels were higher within exosomes than free in plasma. Moderate correlations were found between exosomal HSP70 and CDR, FTLD-CDR, and extension of hypometabolism. Our results suggest modifications in the level of exosomal HSP70 during the course of neurodegeneration, regardless of AD or FTD, and therefore HSP70 could have a potential role in the follow-up of these disorders.
Identifiants
pubmed: 31498123
pii: JAD190545
doi: 10.3233/JAD-190545
doi:
Substances chimiques
Biomarkers
0
HSP70 Heat-Shock Proteins
0
Radiopharmaceuticals
0
Fluorodeoxyglucose F18
0Z5B2CJX4D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM