Genetic and antigenic characteristics of a human influenza C virus clinical isolate.
antigenic evolution
genesis
influenza C virus
phylogenetic evolution
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
08
08
2019
accepted:
02
09
2019
pubmed:
10
9
2019
medline:
15
12
2020
entrez:
10
9
2019
Statut:
ppublish
Résumé
Unlike influenza A and B viruses that infect humans and cause severe diseases in seasonal epidemics, influenza C virus (ICV) is a ubiquitous childhood pathogen typically causing mild respiratory symptoms. ICV infections are rarely diagnosed and less research has been performed on it despite the virus being capable of causing severe disease in infants. Here we report on the isolation of a human ICV from a child with acute respiratory disease, provisionally designated C/Victoria/2/2012 (C/Vic). The full-length genome sequence and phylogenetic analysis revealed that the hemagglutinin-esterase-fusion (HEF) gene of C/Vic was derived from C/Sao Paulo lineage, while its PB2 and P3 genes evolved separately from all characterized historical ICV isolates. Furthermore, antigenic analysis using the hemagglutination inhibition (HI) assay found that 1947 C/Taylor virus (C/Taylor lineage) was antigenically more divergent from1966 C/Johannesburg (C/Aichi lineage) than from 2012 C/Vic. Structure modeling of the HEF protein identified two mutations in the 170-loop of the HEF protein around the receptor-binding pocket as a possible antigenic determinant responsible for the discrepant HI results. Taken together, results of our studies reveal novel insights into the genetic and antigenic evolution of ICV and provide a framework for further investigation of its molecular determinants of antigenic property and replication.
Identifiants
pubmed: 31498448
doi: 10.1002/jmv.25589
pmc: PMC6901781
mid: NIHMS1049641
doi:
Substances chimiques
Antigens, Viral
0
RNA, Viral
0
Viral Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
161-166Subventions
Organisme : NIAID NIH HHS
ID : R01 AI141889
Pays : United States
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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