Cord Blood Metabolomics: Association With Newborn Anthropometrics and C-Peptide Across Ancestries.
Adiposity
Adult
Anthropometry
Biomarkers
/ blood
Birth Weight
C-Peptide
/ blood
Cross-Sectional Studies
Ethnicity
/ statistics & numerical data
Female
Fetal Blood
/ metabolism
Glucose Tolerance Test
Humans
Hyperglycemia
/ blood
Hyperinsulinism
/ blood
Infant, Newborn
Male
Metabolomics
/ methods
Native Hawaiian or Other Pacific Islander
/ ethnology
Obesity
/ blood
Pregnancy
Pregnancy Outcome
Severity of Illness Index
Journal
The Journal of clinical endocrinology and metabolism
ISSN: 1945-7197
Titre abrégé: J Clin Endocrinol Metab
Pays: United States
ID NLM: 0375362
Informations de publication
Date de publication:
01 10 2019
01 10 2019
Historique:
received:
30
01
2019
accepted:
28
06
2019
entrez:
10
9
2019
pubmed:
10
9
2019
medline:
30
5
2020
Statut:
ppublish
Résumé
Newborn adiposity is associated with childhood obesity. Cord blood metabolomics is one approach that can be used to understand early-life contributors to adiposity and insulin resistance. To determine the association of cord blood metabolites with newborn adiposity and hyperinsulinemia in a multiethnic cohort of newborns. Cross-sectional, observational study. Hyperglycemia and Adverse Pregnancy Outcome study. One thousand six hundred multiethnic mother-newborn pairs. Cord blood C-peptide, birthweight, and newborn sum of skinfolds. Meta-analyses across four ancestry groups (Afro-Caribbean, Northern European, Thai, and Mexican American) demonstrated significant associations of cord blood metabolites with cord blood C-peptide, birthweight, and newborn sum of skinfolds. Several metabolites, including branched-chain amino acids (BCAAs), medium- and long-chain acylcarnitines, nonesterified fatty acids, and triglycerides were negatively associated with cord C-peptide but positively associated with birthweight and/or sum of skinfolds. 1,5-Anhydroglucitol, an inverse marker of recent maternal glycemia, was significantly inversely associated with birthweight and sum of skinfolds. Network analyses revealed groups of interrelated amino acid, acylcarnitine, and fatty acid metabolites associated with all three newborn outcomes. Cord blood metabolites are associated with newborn size and cord blood C-peptide levels after adjustment for maternal body mass index and glucose during pregnancy. Negative associations of metabolites with C-peptide at birth were observed. 1,5-Anhydroglucitol appears to be a marker of adiposity in newborns. BCAAs were individually associated with birthweight and demonstrated possible associations with newborn adiposity in network analyses.
Identifiants
pubmed: 31498869
pii: 5527769
doi: 10.1210/jc.2019-00238
pmc: PMC6735762
doi:
Substances chimiques
Biomarkers
0
C-Peptide
0
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4459-4472Subventions
Organisme : NICHD NIH HHS
ID : R01 HD034242
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002548
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD034243
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001422
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK095963
Pays : United States
Informations de copyright
Copyright © 2019 Endocrine Society.
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