Developmental responses to early-life adversity: Evolutionary and mechanistic perspectives.
developmental constraints
developmental plasticity
glucocorticoids
maternal capital
microbiome
predictive adaptive responses
Journal
Evolutionary anthropology
ISSN: 1520-6505
Titre abrégé: Evol Anthropol
Pays: United States
ID NLM: 9306331
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
15
02
2018
revised:
28
03
2019
accepted:
11
06
2019
pubmed:
10
9
2019
medline:
18
12
2019
entrez:
10
9
2019
Statut:
ppublish
Résumé
Adverse ecological and social conditions during early life are known to influence development, with rippling effects that may explain variation in adult health and fitness. The adaptive function of such developmental plasticity, however, remains relatively untested in long-lived animals, resulting in much debate over which evolutionary models are most applicable. Furthermore, despite the promise of clinical interventions that might alleviate the health consequences of early-life adversity, research on the proximate mechanisms governing phenotypic responses to adversity have been largely limited to studies on glucocorticoids. Here, we synthesize the current state of research on developmental plasticity, discussing both ultimate and proximate mechanisms. First, we evaluate the utility of adaptive models proposed to explain developmental responses to early-life adversity, particularly for long-lived mammals such as humans. In doing so, we highlight how parent-offspring conflict complicates our understanding of whether mothers or offspring benefit from these responses. Second, we discuss the role of glucocorticoids and a second physiological system-the gut microbiome-that has emerged as an additional, clinically relevant mechanism by which early-life adversity can influence development. Finally, we suggest ways in which nonhuman primates can serve as models to study the effects of early-life adversity, both from evolutionary and clinical perspectives.
Substances chimiques
Glucocorticoids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
249-266Subventions
Organisme : Leakey Foundation
Organisme : NIA NIH HHS
ID : NIA-R00AG051764
Pays : United States
Organisme : National Science Foundation
ID : BCS-1723228
Organisme : National Science Foundation
ID : BCS-1723237
Organisme : National Science Foundation
ID : SBE-1714730
Organisme : NIA NIH HHS
ID : NIA-R00AG051764
Pays : United States
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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