Birth dimensions, severe mental illness and risk of type 2 diabetes in a cohort of Danish men born in 1953.
Birth weight
Ponderal index
Schizophrenia
Severe mental illness
Type 2 diabetes mellitus
Journal
European psychiatry : the journal of the Association of European Psychiatrists
ISSN: 1778-3585
Titre abrégé: Eur Psychiatry
Pays: England
ID NLM: 9111820
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
13
06
2019
revised:
29
08
2019
accepted:
29
08
2019
pubmed:
11
9
2019
medline:
1
8
2020
entrez:
11
9
2019
Statut:
ppublish
Résumé
Birth dimensions have been associated with increased risk of both, severe mental illness and type 2 diabetes in adulthood, however, any influence on their co-occurrence has never been examined. This cohort study examine whether birth weight/ponderal index explain or modify the later association between severe mental illness and risk of type 2 diabetes. The Metropolit cohort included 10,863 Danish men born in 1953 with information from age at conscription (between1971-84) until February 15 After 47.1 years of follow-up, 848 (7.8%) and 1320 (12.2%) men developed a severe mental illness or diabetes, respectively. Men with severe mental illness presented higher risk of subsequent diabetes (HR = 1.92; 95%CI, 1.61-2.30). This association was stronger in severe mental ill men with low birth weight (HR = 3.58; 95%CI, 2.11-6.07), than in those normal birth weight (HR = 1.79; 95%CI, 1.45-2.20). This effect modification was most evident for men diagnosed with schizophrenia. Birth information on birth weight/ponderal index could be of interest in diabetes screening on severe mental ill populations (especially in schizophrenia) since they might play a critical role in the increased risk of type 2 diabetes following severe mental illness.
Sections du résumé
BACKGROUND
Birth dimensions have been associated with increased risk of both, severe mental illness and type 2 diabetes in adulthood, however, any influence on their co-occurrence has never been examined. This cohort study examine whether birth weight/ponderal index explain or modify the later association between severe mental illness and risk of type 2 diabetes.
METHODS
The Metropolit cohort included 10,863 Danish men born in 1953 with information from age at conscription (between1971-84) until February 15
RESULTS
After 47.1 years of follow-up, 848 (7.8%) and 1320 (12.2%) men developed a severe mental illness or diabetes, respectively. Men with severe mental illness presented higher risk of subsequent diabetes (HR = 1.92; 95%CI, 1.61-2.30). This association was stronger in severe mental ill men with low birth weight (HR = 3.58; 95%CI, 2.11-6.07), than in those normal birth weight (HR = 1.79; 95%CI, 1.45-2.20). This effect modification was most evident for men diagnosed with schizophrenia.
CONCLUSIONS
Birth information on birth weight/ponderal index could be of interest in diabetes screening on severe mental ill populations (especially in schizophrenia) since they might play a critical role in the increased risk of type 2 diabetes following severe mental illness.
Identifiants
pubmed: 31505317
pii: S0924-9338(19)30149-X
doi: 10.1016/j.eurpsy.2019.08.015
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-9Informations de copyright
Copyright © 2019 Elsevier Masson SAS. All rights reserved.