Logical design of oral glucose ingestion pattern minimizing blood glucose in humans.
Health care
Mathematics and computing
Systems biology
Journal
NPJ systems biology and applications
ISSN: 2056-7189
Titre abrégé: NPJ Syst Biol Appl
Pays: England
ID NLM: 101677786
Informations de publication
Date de publication:
2019
2019
Historique:
received:
05
03
2019
accepted:
06
08
2019
entrez:
12
9
2019
pubmed:
12
9
2019
medline:
28
4
2020
Statut:
epublish
Résumé
Excessive increase in blood glucose level after eating increases the risk of macroangiopathy, and a method for not increasing the postprandial blood glucose level is desired. However, a logical design method of the dietary ingestion pattern controlling the postprandial blood glucose level has not yet been established. We constructed a mathematical model of blood glucose control by oral glucose ingestion in three healthy human subjects, and predicted that intermittent ingestion 30 min apart was the optimal glucose ingestion patterns that minimized the peak value of blood glucose level. We confirmed with subjects that this intermittent pattern consistently decreased the peak value of blood glucose level. We also predicted insulin minimization pattern, and found that the intermittent ingestion 30 min apart was optimal, which is similar to that of glucose minimization pattern. Taken together, these results suggest that the glucose minimization is achieved by suppressing the peak value of insulin concentration, rather than by enhancing insulin concentration. This approach could be applied to design optimal dietary ingestion patterns.
Identifiants
pubmed: 31508240
doi: 10.1038/s41540-019-0108-1
pii: 108
pmc: PMC6718521
doi:
Substances chimiques
Blood Glucose
0
C-Peptide
0
Insulin
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
31Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing interests.
Références
J Clin Invest. 2004 Feb;113(4):635-45
pubmed: 14966573
J Biol Chem. 1994 Mar 4;269(9):6275-8
pubmed: 8119974
Diabetes Technol Ther. 2015 Nov;17(11):787-94
pubmed: 26171659
Diabetes Metab Rev. 1994 Jul;10(2):119-50
pubmed: 7956676
Am J Physiol. 1979 Jun;236(6):E667-77
pubmed: 443421
J Clin Invest. 1998 Mar 15;101(6):1354-61
pubmed: 9502777
J Diabetes Sci Technol. 2007 May;1(3):323-30
pubmed: 19885087
J Biol Chem. 2001 Nov 2;276(44):41245-54
pubmed: 11533050
PLoS One. 2013 Aug 29;8(8):e70875
pubmed: 24009656
Nat Commun. 2017 May 04;8:15259
pubmed: 28469281
Ann Biomed Eng. 2007 Jul;35(7):1286-300
pubmed: 17393338
Am J Physiol Endocrinol Metab. 2003 Apr;284(4):E671-8
pubmed: 12626323
Diabetes. 1997 Apr;46(4):701-10
pubmed: 9075814
Ann Biomed Eng. 2006 Aug;34(8):1343-54
pubmed: 16838125
Proc Natl Acad Sci U S A. 1987 Oct;84(20):7005-8
pubmed: 2890159
Am J Clin Nutr. 2004 Aug;80(2):348-56
pubmed: 15277155
Diabetes Obes Metab. 2011 Oct;13 Suppl 1:82-8
pubmed: 21824260
Metabolism. 2001 May;50(5):583-9
pubmed: 11319721
Diabetes Care. 2000 Mar;23(3):295-301
pubmed: 10868854
IEEE Trans Biomed Eng. 2011 Oct;58(10):3020-3
pubmed: 21846600
Am J Physiol Endocrinol Metab. 2001 Nov;281(5):E966-74
pubmed: 11595652
Annu Rev Nutr. 2006;26:1-22
pubmed: 16848698
Diabetes Care. 2006 May;29(5):1130-9
pubmed: 16644654
PLoS One. 2015 Dec 01;10(12):e0143880
pubmed: 26623647
Am J Physiol Endocrinol Metab. 2011 Jun;300(6):E955-65
pubmed: 21364121
Diabet Med. 2012 Aug;29(8):972-9
pubmed: 22443306
Am J Physiol Endocrinol Metab. 2014 Mar;306(6):E627-34
pubmed: 24425760
Mol Endocrinol. 1989 Jun;3(6):1014-21
pubmed: 2739653
IEEE Trans Biomed Eng. 2006 Dec;53(12 Pt 1):2472-8
pubmed: 17153204
Nature. 1983 Apr 21;302(5910):716-8
pubmed: 6835407
Am J Physiol Endocrinol Metab. 2013 Apr 15;304(8):E819-25
pubmed: 23443923
Biophys Physicobiol. 2017 Feb 22;14:29-40
pubmed: 28275530
Cell Rep. 2016 Mar 15;14(10):2362-74
pubmed: 26947072
Diabetes Care. 2002 Feb;25(2):275-8
pubmed: 11815495
Basic Clin Pharmacol Toxicol. 2017 Oct;121(4):290-297
pubmed: 28374974
Diabetes. 1993 May;42(5):658-61
pubmed: 8482423
Biochem Biophys Res Commun. 1984 Apr 30;120(2):641-9
pubmed: 6329177
Diabetologia. 2009 May;52(5):863-72
pubmed: 19266181
Sci Signal. 2016 Nov 22;9(455):ra112
pubmed: 27879394
Diabetes. 2008 Mar;57(3):678-87
pubmed: 18057091
Diabet Med. 1998 Jul;15(7):539-53
pubmed: 9686693
Nat Med. 2002 Jul;8(7):738-42
pubmed: 12068290
J Diabetes Investig. 2010 Apr 22;1(1-2):8-23
pubmed: 24843404
Diabetologia. 2004 Mar;47(3):385-394
pubmed: 14985967
J Korean Med Sci. 2014 Mar;29(3):378-85
pubmed: 24616587
NPJ Syst Biol Appl. 2018 Mar 14;4:14
pubmed: 29560274
Diabetes Technol Ther. 2016 Jan;18(1):39-46
pubmed: 26756104