Plasma Type I IFN Protein Concentrations in Human Tuberculosis.
Adult
Aged
Blood Proteins
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
France
Humans
Immunologic Factors
Infant
Interferon Type I
/ blood
Interferon-alpha
/ blood
Interferon-beta
/ blood
Male
Middle Aged
Mycobacterium tuberculosis
South Africa
Tuberculosis
/ immunology
Young Adult
Cytokines
IFNa
IFNb
interferon
protein biomarker
tuberculosis
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2019
2019
Historique:
received:
13
05
2019
accepted:
31
07
2019
entrez:
12
9
2019
pubmed:
12
9
2019
medline:
14
7
2020
Statut:
epublish
Résumé
Tuberculosis (TB) remains one of the leading causes of mortality worldwide, and a lack of understanding of basic disease pathogenesis is hampering development of new vaccines and treatments. Multiple studies have previously established a role for type I interferon (IFN) in TB disease. Type I IFNs are critical immune mediators for host responses to viral infection, yet their specific influence in bacterial infection remains unclear. As IFN-stimulated genes (ISGs) can have both stimulatory and inhibitory effects on immune function, clarifying the role of type I interferon in TB remains an important question. The quantification of interferon proteins in the circulation of patients has been restricted until the recent development of digital ELISA. To test the hypothesis that patients with active TB disease have elevated circulating type I IFN we quantified plasma IFNα and β proteins with Simoa digital ELISA in patients with active disease and asymptomatic
Identifiants
pubmed: 31508378
doi: 10.3389/fcimb.2019.00296
pmc: PMC6713931
doi:
Substances chimiques
Blood Proteins
0
Immunologic Factors
0
Interferon Type I
0
Interferon-alpha
0
Interferon-beta
77238-31-4
Banques de données
figshare
['10.6084/m9.figshare.8799131']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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