[Effect of propofol on myelin basic protein expression and myelination of oligodendrocytes in neonatal SD rats].


Journal

Nan fang yi ke da xue xue bao = Journal of Southern Medical University
ISSN: 1673-4254
Titre abrégé: Nan Fang Yi Ke Da Xue Xue Bao
Pays: China
ID NLM: 101266132

Informations de publication

Date de publication:
30 Aug 2019
Historique:
entrez: 13 9 2019
pubmed: 13 9 2019
medline: 19 9 2019
Statut: ppublish

Résumé

To investigate the effects of different doses of propofol on myelin basic protein (MBP) synthesis and myelination of oligodendrocytes in neonatal SD rats. A total of 57 neonatal SD rats (7 days old) were randomly divided into control group ( Compared with the control group, the neonatal rats with propofol injections showed significantly down-regulated expressions of In neonatal SD rats, propofol can dose-dependently promote oligodendrocyte apoptosis, decrease MBP expressions in the brain, and suppress myelin formation in the corpus callosum and the internal capsule.

Identifiants

pubmed: 31511216
doi: 10.12122/j.issn.1673-4254.2019.08.12
pmc: PMC6765605
doi:

Substances chimiques

Myelin Basic Protein 0
RNA, Messenger 0
Propofol YI7VU623SF

Types de publication

Journal Article

Langues

chi

Sous-ensembles de citation

IM

Pagination

950-956

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Auteurs

Xin Zhang (X)

Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Chunshui Lin (C)

Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Peipei Guo (P)

Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Jun Qin (J)

Department of Anesthesiology, Longgang Orthopedics Hospital, Shenzhen 518116, China.

Xiuxiu Qin (X)

Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Weidong Liang (W)

Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

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Classifications MeSH