Importance of a Liver Biopsy in the Management of Wilson Disease.
Wilson disease
hepatic copper content
liver biopsy
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
01 Jan 2020
01 Jan 2020
Historique:
pubmed:
13
9
2019
medline:
14
4
2020
entrez:
13
9
2019
Statut:
ppublish
Résumé
A 37-year-old Wilson disease patient treated with D-penicillamine visited our hospital for the evaluation of his liver function. Laboratory data showed a low serum copper level and ceruloplasmin. The ratio of urinary copper to urinary creatinine in a spot urinary analysis after 4 days' cessation of D-penicillamine was under 0.1. We concluded that the copper chelation was excessive and changed D-penicillamine to zinc acetate. However, his liver function test results did not normalize. We performed a liver biopsy and discovered a high copper content. The liver dysfunction was improved after resuming chelating therapy. Accurate measurement of the hepatic copper content via a biopsy is important for the adequate management of this disease.
Identifiants
pubmed: 31511488
doi: 10.2169/internalmedicine.3440-19
pmc: PMC6995705
doi:
Substances chimiques
Chelating Agents
0
Copper
789U1901C5
Ceruloplasmin
EC 1.16.3.1
Zinc Acetate
FM5526K07A
Penicillamine
GNN1DV99GX
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
77-81Références
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