DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.
Animals
Cell Death
/ genetics
Cell Line
Cell Survival
/ genetics
DEAD-box RNA Helicases
/ genetics
Gene Expression Profiling
Gene Expression Regulation, Developmental
/ genetics
HEK293 Cells
Humans
Inflammasomes
/ genetics
Macrophages
/ cytology
Mice
NLR Family, Pyrin Domain-Containing 3 Protein
/ genetics
Stress, Physiological
/ genetics
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
27
11
2018
accepted:
07
08
2019
pubmed:
13
9
2019
medline:
31
3
2020
entrez:
13
9
2019
Statut:
ppublish
Résumé
The cellular stress response has a vital role in regulating homeostasis by modulating cell survival and death. Stress granules are cytoplasmic compartments that enable cells to survive various stressors. Defects in the assembly and disassembly of stress granules are linked to neurodegenerative diseases, aberrant antiviral responses and cancer
Identifiants
pubmed: 31511697
doi: 10.1038/s41586-019-1551-2
pii: 10.1038/s41586-019-1551-2
pmc: PMC6980284
mid: NIHMS1052898
doi:
Substances chimiques
Inflammasomes
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
DEAD-box RNA Helicases
EC 3.6.4.13
Ddx3x protein, mouse
EC 3.6.4.13
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
590-594Subventions
Organisme : NIH HHS
ID : R0CA1129541
Pays : United States
Organisme : NIH HHS
ID : CA163507
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI101935
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI124346
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA021765
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA163507
Pays : United States
Organisme : NIH HHS
ID : AR056296
Pays : United States
Organisme : NIH HHS
ID : AI101935
Pays : United States
Organisme : NIH HHS
ID : AI124346
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI101935
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA096832
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR056296
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA021765-35
Pays : United States
Commentaires et corrections
Type : CommentIn
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