Synthesis of benzotriazoles derivatives and their dual potential as α-amylase and α-glucosidase inhibitors in vitro: Structure-activity relationship, molecular docking, and kinetic studies.

Diabetes Mellitus / drug therapy Enzyme Inhibitors / chemical synthesis Humans Hypoglycemic Agents / chemical synthesis Molecular Docking Simulation Molecular Targeted Therapy Structure-Activity Relationship Triazoles / chemical synthesis alpha-Amylases / antagonists & inhibitors alpha-Glucosidases / metabolism
Benzotriazoles Diabetes In silico studies Kinetic studies α-Amylase inhibition α-glucosidase inhibition

Journal

European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510

Informations de publication

Date de publication:
01 Dec 2019
Historique:
received: 14 06 2019
revised: 09 08 2019
accepted: 02 09 2019
pubmed: 13 9 2019
medline: 15 1 2020
entrez: 13 9 2019
Statut: ppublish

Résumé

Benzotriazoles (4-6) were synthesized which were further reacted with different substituted benzoic acids and phenacyl bromides to synthesize benzotriazole derivatives (7-40). The synthetic compounds (7-40) were characterized via different spectroscopic techniques including EI-MS, HREI-MS,

Identifiants

DOI: 10.1016/j.ejmech.2019.111677 PMID: 31514061
pubmed: 31514061
pii: S0223-5234(19)30821-9
doi: 10.1016/j.ejmech.2019.111677
pii:
doi:

Substances chimiques

Enzyme Inhibitors 0
Hypoglycemic Agents 0
Triazoles 0
benzotriazole 86110UXM5Y
alpha-Amylases EC 3.2.1.1
alpha-Glucosidases EC 3.2.1.20

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

111677

Informations de copyright

Copyright © 2019 Elsevier Masson SAS. All rights reserved.

Auteurs

Shehryar Hameed (S)

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.

Faiza Seraj (F)

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.

Rafaila Rafique (R)

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.

Sridevi Chigurupati (S)

Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraidah, 52571, Saudi Arabia.

Abdul Wadood (A)

Department of Biochemistry, Computational Medicinal Chemistry Laboratory, UCSS, Abdul Wali Khan University, Mardan, Pakistan.

Ashfaq Ur Rehman (AU)

Department of Biochemistry, Computational Medicinal Chemistry Laboratory, UCSS, Abdul Wali Khan University, Mardan, Pakistan.

Vijayan Venugopal (V)

Faculty of Pharmacy, AIMST University, Kedah, 08100, Malaysia.

Uzma Salar (U)

Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.

Muhammad Taha (M)

Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam, 31441, Saudi Arabia.

Khalid Mohammed Khan (KM)

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan; Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam, 31441, Saudi Arabia. Electronic address: khalid.khan@iccs.edu.

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Classifications MeSH

questionsmedicales.fr › Maladies endocriniennes › Diabète › Synthesis of benzotriazoles derivatives and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Synthesis of benzotriazoles derivatives and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthesis of benzotriazoles derivatives and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Synthesis of benzotriazoles derivatives and...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Synthesis of benzotriazoles derivatives and...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Thérapie moléculaire ciblée › Synthesis of benzotriazoles derivatives and...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Synthesis of benzotriazoles derivatives and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Triazoles › Synthesis of benzotriazoles derivatives and...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Amylases › alpha-Amylases › Synthesis of benzotriazoles derivatives and...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Glucosidases › alpha-Glucosidase › Synthesis of benzotriazoles derivatives and...